METHODS AND COMPOSITIONS FOR INHIBITING CD32B EXPRESSING CELLS
The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.
1 . A method of treating cancer in a patient in need of such treatment, comprising:
administering to the patient an anti-human CD40 antibody comprising a light chain and a heavy chain, the heavy chain comprising a human IgG1 Fc domain comprising a S267E amino acid substitution, wherein the numbering is according to the EU index as in Kabat.
2 . The method of claim 1 , wherein the cancer is pancreatic cancer.
3 . The method of claim 1 , comprising administering the anti-human CD40 antibody in combination with one or more chemotherapeutic agents.
4 . The method of claim 3 , wherein the chemotherapeutic agent is gemcitabine.
5 . The method of claim 4 , wherein the one or more chemotherapeutic agents are gemcitabine in combination with paclitaxel.
6 . The method of claim 4 , comprising administering the anti-human CD40 antibody in combination with a second antibody.
7 . The method of claim 5 , comprising administering the anti-human CD40 antibody in combination with a second antibody.