High osmolarity antimicrobial composition containing one or more organic solvents
A composition that can solvate biofilms and disrupt bacterial cell walls acts to both kill the bacteria by cell lysis and remove the biofilm. This solvent-containing composition is effective against a broad spectrum of microbes and can be used on a variety of surfaces, both living and inanimate. The polarity of the solvent component of the composition is lower than that of pure water so that the composition exhibits increased efficacy in solvating the macromolecular matrix of a biofilm and in penetrating bacterial cell walls.
1. A method for rinsing a surgical site, said method comprising introducing to said site a liquid composition that consists of
(1) a solvent component exhibiting a δ p value of from 13.7 to 15.4 MPa 1/2 that consists of water and one or more C 1 -C 16 acyclic alcohols; and
(2) a solute component that comprises cationic surfactant, dissociation products of at least one monoprotic organic acid, and dissociation products of at least one salt of at least one monoprotic organic acid,
said composition having a pH of greater than about 3 but less than 5.0 and an effective solute concentration of from 1 to 2.33 Osm/L.
2. The method of claim 1 wherein said composition exhibits a pH of less than 4.6.
3. The method of claim 2 wherein said composition exhibits a pH of less than 4.4.
4. The method of claim 3 wherein said composition exhibits a pH of less than 4.2.
5. The method of claim 1 wherein said one or more C 1 -C 16 acyclic alcohols of said composition comprises ethanol.
6. The method of claim 5 wherein said one or more C 1 -C 16 acyclic alcohols is ethanol.
7. The method of claim 1 wherein said at least one monoprotic organic acid of said composition comprises acetic acid.
8. The method of claim 7 wherein said at least one monoprotic organic acid is acetic acid.
9. The method of claim 7 wherein said at least one salt of at least one monoprotic organic acid comprises an acetate.
10. The method of claim 9 wherein said at least one salt of at least one monoprotic organic acid is an acetate.
11. The method of claim 1 wherein said composition has an effective solute concentration of at least 1.5 Osm/L.
12. The method of claim 11 wherein said composition has an effective solute concentration of at least 1.75 Osm/L.
13. A process for reducing microbial contamination during surgery, said process comprising introducing to a surgical site a liquid wash composition that consists of
(1) a solvent component exhibiting a δ p value of from 13.7 to 15.4 MPa 1/2 that consists of water and ethanol; and
(2) a solute component that consists of cationic surfactant, dissociation products of a monoprotic organic acid, and dissociation products of a salt of a monoprotic organic acid,
said composition having a pH of greater than about 3 but less than 4.4 and an effective solute concentration of from 1 to 2.33 Osm/L.
14. The process of claim 13 wherein said monoprotic organic acid of said composition is acetic acid.
15. The process of claim 14 wherein said salt of a monoprotic organic acid is an acetate.
16. The process of claim 13 wherein said composition has an effective solute concentration of at least 1.5 Osm/L.
17. The process of claim 16 wherein said composition has an effective solute concentration of at least 1.75 Osm/L.
18. A process for reducing microbial contamination during surgery, said process comprising introducing to a surgical site a liquid wash composition that consists of
(1) a solvent component exhibiting a δ p value of from 13.7 to 15.4 MPa 1/2 that consists of water and ethanol; and
(2) a solute component that consists of cationic surfactant, dissociation products of acetic acid, and dissociation products of a salt of a monoprotic organic acid,
said composition having a pH of greater than about 3 but less than 4.4 and an effective solute concentration of at least 1.5 Osm/L.
19. The process of claim 18 wherein said salt of a monoprotic organic acid is an acetate.
20. The process of claim 18 wherein said composition has an effective solute concentration of at least 1.75 Osm/L.