Stable pharmaceutical composition and methods of using same
The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.
1. A method of reducing a risk of stroke in a subject on statin therapy and having atrial fibrillation and elevated triglycerides, the method comprising administering to the subject about 4 g of ethyl eicosapentaenoate per day.
2. The method of claim 1 , wherein the administering lowers triglycerides in the subject.
3. The method of claim 1 , wherein the subject has a baseline LDL-C level of about 40 mg/dL to about 100 mg/dL.
4. The method of claim 1 , wherein the ethyl eicosapentaenoate is present in a pharmaceutical composition and the ethyl eicosapentaenoate comprises at least about 96 wt. % of all omega-3 fatty acids in the pharmaceutical composition.
5. The method of claim 4 , wherein about 1 g of the pharmaceutical composition is present in each of 4 capsules.