IP Library › Granted Patent US 12,279,808
Granted Patent B2
US 12,279,808 · App. 16/701,890 · Granted Apr 22, 2025

Systems and methods for therapeutic nasal neuromodulation

Inventors: David Townley (Clare, IE); Brian Shields (Galway, IE)
Assignee: Neurent Medical Limited
A61B18/1485A61B18/14A61B34/10A61B34/20A61N1/0546A61N1/403G06T7/0012A61B2017/00199A61B2017/00292A61B2017/00424A61B2017/00867A61B2018/0016A61B2018/00166A61B2018/00214A61B2018/00303A61B2018/00327A61B2018/00434A61B2018/00577A61B2018/00654A61B2018/00815A61B2018/00821A61B2018/00875A61B2018/00922A61B2018/00946A61B18/02A61B18/1206A61B2018/1253A61B2018/126A61B2018/1407A61B2018/144A61B2018/1467A61B2018/1475A61B2018/1823A61B18/20A61B2034/102A61B2090/3735A61B2090/3762A61B2090/378A61B90/94A61B2218/007
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Quick Facts
Patent No.
US 12,279,808
App. No.
16/701,890
Granted
Apr 22, 2025
Kind
B2
Abstract

The invention provides systems and methods for therapeutically modulating nerves in or associated with a nasal region of a patient for the treatment of a rhinosinusitis condition. The system includes a device including a multi-segment end effector for delivering energy to one or more target sites within the nasal cavity of the patient. The multi-segment end effector includes a first segment and a separate second segment, wherein each of the first and second segments is transformable between a retracted configuration and an expanded deployed configuration, the first segment having a first geometry when in the deployed configuration to complement anatomy at a first location within the nasal cavity and a second segment having a second geometry when in the deployed configuration to complement anatomy at a second location within the nasal cavity.

Claims (28)

1. A handheld device for treating a condition within a nasal cavity of a patient, the handheld device comprising:

a shaft;

a multi-segment end effector operably associated with the shaft and configured for delivering energy to one or more target sites within the nasal cavity of the patient, the multi-segment end effector comprising a retractable and expandable first and second segment; and

a handle operably associated with the shaft and the multi-segment end effector, the handle having at least a first user-manipulatable mechanism for transitioning each of the first and second segments between retracted and expandable deployed configurations and a second user-manipulatable mechanism for control of energy output from each of the first and second segments;

wherein the first segment of the multi-segment end effector is provided on the shaft closer to a proximal portion thereof and comprises:

a first set of flexible support elements of a first size, each comprising a single deformable wire and an array of electrodes positioned at separate and discrete portions thereon, the first set of flexible support elements having a deployed architecture when the first segment is in the expanded deployed configuration in which the first set of flexible support elements extend in a first outward direction relative to a longitudinal axis along which the shaft lies and are positioned within a first half of the first segment and cooperatively form an inwardly extending first concave shape; and

a second set of flexible support elements of a second size that is different than the first size of the first set of flexible support elements, each comprising a single deformable wire and an array of electrodes positioned at separate and discrete portions thereon, the second set of flexible support elements having a deployed architecture when the first segment is in the expanded deployed configuration in which the second set of flexible support elements extend in a second outward direction relative to the longitudinal axis and substantially opposite the first outward direction and are positioned within a second half of the first segment and cooperatively form an inwardly extending second concave shape opposing the first concave shape; and

wherein the separate second segment of the multi-segment end effector is provided on the shaft closer to a distal portion thereof and longitudinally spaced apart from the first segment along the shaft, the second segment is transformable between the retracted configuration and the expanded deployed configuration, the second segment comprises a third set of flexible support elements, wherein each one of the third set of flexible support elements comprises a single deformable wire defining a loop-shaped support element that comprises an array of electrodes positioned at separate and discrete portions thereon, wherein each of the loop-shaped support elements defines a freely independent distal-most portion thereof that extends in an outward direction away from the distal portion of the shaft to define a distal-most end of the handheld device when the second segment is in either of the retracted and expanded deployed configurations.

2. The handheld device of claim 1 , wherein the first set of flexible support elements conforms to and complements a shape of a first anatomical structure at a first location within the nasal cavity when the first segment is in the expanded deployed configuration and the third set of flexible support elements conforms to and complements a shape of a second anatomical structure at a second location within the nasal cavity when the second segment is in the expanded deployed configuration.

3. The handheld device of claim 2 , wherein the first and second anatomical structures are selected from the group consisting of inferior turbinate, middle turbinate, superior turbinate, inferior meatus, middle meatus, superior meatus, pterygopalatine region, pterygopalatine fossa, sphenopalatine foramen, accessory sphenopalatine foramen (ae), and sphenopalatine micro-foramen(ae).

4. The handheld device of claim 2 , wherein the first, second, and third sets of flexible support elements comprise deformable composite wires, said composite wires comprising shape memory material.

5. The handheld device of claim 2 , wherein the arrays of electrodes of the first and third flexible support elements are configured to deliver radiofrequency (RF) energy to tissue at the one or more target sites with respect to the corresponding first and second locations, respectively, within the nasal cavity, wherein the one or more target sites are associated with parasympathetic nerve supply.

6. The handheld device of claim 5 , wherein the arrays of electrodes of the first and third flexible support elements are configured to deliver RF energy at a level sufficient to therapeutically modulate postganglionic parasympathetic nerves innervating nasal mucosa at an innervation pathway within the nasal cavity of the patient.

7. The handheld device of claim 6 , wherein the condition is selected from the group consisting of allergic rhinitis, non-allergic rhinitis, chronic rhinitis, acute rhinitis, chronic sinusitis, acute sinusitis, chronic rhinosinusitis, acute rhinosinusitis, and medical resistant rhinitis.

8. A method for treating a condition within a nasal cavity of a patient, the method comprising:

advancing a multi-segment end effector of a handheld device to one or more target sites within the nasal cavity of the patient, the handheld device comprising: a shaft; the multi-segment end effector operably associated with the shaft and configured to deliver energy to the one or more target sites within the nasal cavity of the patient, the multi-segment end effector comprising a retractable and expandable first and second segment; and a handle operably associated with the shaft and the multi-segment end effector, the handle having at least a first user-manipulatable mechanism for transitioning the first and second segments between retracted and expandable deployed configurations and a second user-manipulatable mechanism for control of energy output from each of the first and second segments;

wherein the first segment of the multi-segment end effector is provided on the shaft closer to a proximal portion thereof and comprises:

a first set of flexible support elements of a first size, each comprising a single deformable wire and an array of electrodes positioned at separate and discrete portions thereon, the first set of flexible support elements having a deployed architecture when the first segment is in the expanded deployed configuration in which the first set of flexible support elements extend in a first outward direction relative to a longitudinal axis along which the shaft lies and are positioned within a first half of the first segment and cooperatively form an inwardly extending first concave shape; and

a second set of flexible support elements of a second size that is different than the first size of the first set of flexible support elements, each comprising a single deformable wire and an array of electrodes positioned at separate and discrete portions thereon, the second set of flexible support elements having a deployed architecture when the first segment is in the expanded deployed configuration in which the second set of flexible support elements extend in a second outward direction relative to the longitudinal axis and substantially opposite the first outward direction and are positioned within a second half of the first segment and cooperatively form an inwardly extending second concave shape opposing the first concave shape; and

wherein the separate second segment of the multi-segment end effector is provided on the shaft closer to a distal portion thereof and longitudinally spaced apart from the first segment along the shaft, the second segment is transformable between the retracted configuration and the expanded deployed configuration, the second segment comprises a third set of flexible support elements, wherein each one of the third set of flexible support elements comprises a single deformable wire defining a loop-shaped support element that comprises an array of electrodes positioned at separate and discrete portions thereon, wherein each of the loop-shaped support elements defines a freely independent distal-most portion thereof that extends in an outward direction away from the distal portion of the shaft to define a distal-most end of the handheld device when the second segment is in either of the retracted and expanded deployed configurations;

deploying the first and second segments at respective first and second locations within the nasal cavity; and

delivering energy, via the array of electrodes provided via the first and second segments, to tissue at the one or more target sites with respect to the first and second locations.

9. The method of claim 8 , wherein the first set of flexible support elements conforms to and complements a shape of a first anatomical structure at the first location within the nasal cavity when the first segment is in the expanded deployed configuration and the third set of flexible support elements conforms to and complements a shape of a second anatomical structure at the second location within the nasal cavity when the second segment is in the expanded deployed configuration.

10. The method of claim 9 , wherein the first and second anatomical structures are selected from the group consisting of inferior turbinate, middle turbinate, superior turbinate, inferior meatus, middle meatus, superior meatus, pterygopalatine region, pterygopalatine fossa, sphenopalatine foramen, accessory sphenopalatine foramen(ae), and sphenopalatine micro-foramen(ae).

11. The method of claim 9 , wherein the first, second, and third sets of support flexible elements comprise deformable composite wires, said composite wires comprising shape memory material.

12. The method of claim 9 , wherein the arrays of electrodes of the first and third flexible support elements are configured to deliver radiofrequency (RF) energy to tissue at the one or more target sites with respect to the corresponding first and second locations, respectively, within the nasal cavity, wherein the one or more target sites are associated with parasympathetic nerve supply.

13. The method of claim 12 , wherein the arrays of electrodes of the first and third flexible support elements are configured to deliver RF energy at a level sufficient to therapeutically modulate postganglionic parasympathetic nerves innervating nasal mucosa at an innervation pathway within the nasal cavity of the patient.

14. The method of claim 13 , wherein the condition is selected from the group consisting of allergic rhinitis, non-allergic rhinitis, chronic rhinitis, acute rhinitis, chronic sinusitis, acute sinusitis, chronic rhinosinusitis, acute rhinosinusitis, and medical resistant rhinitis.

Assignments (2)
SECURITY INTEREST Recorded Oct 18, 2024
From: NEURENT MEDICAL LIMITED
To: CLARET EUROPEAN SPECIALTY LENDING COMPANY III, S.A R.L.
Reel/Frame 068942/0887 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 21, 2020
From: TOWNLEY, DAVID; SHIELDS, BRIAN
To: NEURENT MEDICAL LIMITED
Reel/Frame 051886/0732 →
Continuity (11)
Provisional Application 62896845 · Sep 6, 2019
Provisional Application 62832917 · Apr 12, 2019
Provisional Application 62832928 · Apr 12, 2019
Provisional Application 62832918 · Apr 12, 2019
Provisional Application 62832927 · Apr 12, 2019
Provisional Application 62832925 · Apr 12, 2019
Provisional Application 62832914 · Apr 12, 2019
Provisional Application 62832920 · Apr 12, 2019
Provisional Application 62832923 · Apr 12, 2019
Provisional Application 62778233 · Dec 11, 2018
Related Publication 20200179043A1 · Jun 11, 2020
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