Treatment of cancer with therapeutic monoclonal antibody specific for a tumor associated antigen and an immune adjuvant
The present document describes a method of inhibiting cancer tumor growth in a patient in need thereof, comprising at least a first treatment comprising steps a) and b): a) administering to the patient an immune adjuvant in combination with a therapeutic monoclonal antibody specific for a tumor associated antigen; and b) administering to the patient the immune adjuvant; and a final treatment consisting of administering to the patient the therapeutic monoclonal antibody specific for a tumor associated antigen, wherein time between step a) and step b) is a time sufficient for treatment of the patient with the immune adjuvant, and wherein time between the step b) and the final treatment is from about 10 to about 14 weeks.
1. A method for improving likelihood of survival in a stage III-IV ovarian cancer patient, the method comprising:
(a) administering to a stage III-IV ovarian cancer patient 6 cycles of chemotherapy, wherein in each cycle the patient is administered a platinum-based chemotherapy and a taxane on the same day;
(b) administering to the patient monoclonal antibody mAb-B43.13 concurrently during cycles 1, 3, and 5 of the 6 cycles of chemotherapy; and
(c) administering to the patient in a final dose of monoclonal antibody mAb-B43.13 without concurrent chemotherapy about 10 to about 14 weeks after cycle 5 of the 6 cycles of chemotherapy,
thereby increasing the patient's likelihood of survival in comparison with a control patient who has been diagnosed with stage III-IV ovarian cancer and has received treatment consisting of 6 cycles of chemotherapy consisting of said platinum-based chemotherapy and said taxane administration,
wherein the method comprises no other treatment step in which mAb-B43.13, said platinum-based chemotherapy, or said taxane is administered to the patient, and wherein in step (b) said taxane, said platinum-based chemotherapy, and mAb-B43.13 are administered in this order on the same day.
2. The method of claim 1 , wherein time interval between every two consecutive cycles of the 6 cycles of chemotherapy is 1 week, 2 weeks, or 1 month.
3. The method of claim 1 , wherein time interval between every two consecutive cycles of the 6 cycles of chemotherapy is 3 weeks.
4. The method of claim 1 , wherein step (c) is performed about 12 weeks after cycle 5 of the 6 cycles of chemotherapy.
5. The method of claim 1 , wherein each of said mAb-B43.13, platinum-based chemotherapy, and taxane is intravenously administered.
6. The method of claim 1 , wherein 2 mg of mAb-B43.13 is administered in a volume of 50 ml by a 20-minute infusion.
7. The method of claim 1 , wherein said platinum-based chemotherapy comprises cisplatin, carboplatin, oxaliplatin, nedaplatin, triplatin tetranitrate, phenanthriplatin, picoplatin, satraplatin, or combinations thereof.
8. The method of claim 7 , wherein said platinum-based chemotherapy is carboplatin.
9. The method of claim 1 , wherein said taxane is paclitaxel, docetaxel, or a combination thereof.
10. The method of claim 9 , wherein said taxane is paclitaxel.
11. The method of claim 1 , wherein step (c) comprises no follow-up therapy.