Fluid distributor unit
A fluid distributor unit comprising a channel system where one or more inlet channels (2) starting on an inlet side (3) of the distributor unit branch out successively into several channels (6) ending on the other side of the distributor unit, called the outlet side (4), characterised in that said distributor unit is provided in one single body (1) by free form fabrication.
1. A method to prepare a sanitary fluid distributor unit for processing of biomacromolecules where said fluid distributor unit comprises a three-dimensional tortuous channel system with one or more inlet channels starting on an inlet side of the fluid distributor unit, branching out successively into several curved channels and ending on the other side of the fluid distributor unit, called an outlet side, the method comprising,
i) making a drawing of the three-dimensional tortuous channel system using a computer assisted design (CAD);
ii) simulating fluid flow properties of the three-dimensional tortuous channel system drawn in step i) in a computer system using a computing software;
iii) determining if the simulated fluid flow properties meet a preset constraint: if the simulated fluid flow properties meet a preset constraint, proceed to step iv) and if the simulated fluid flow properties do not meet a preset constraint, repeat steps i)-iii) with a newly designed three-dimensional tortuous channel system; and
iv) producing the three-dimensional tortuous channel system in one single body by free form fabrication, wherein surfaces of the three-dimensional tortuous channel system have a first roughness average Ra of 30-50 microns; and
v) modifying the surfaces of the three-dimensional tortuous channel system produced by the free form fabrication, wherein the modified surfaces have a second roughness average Ra of less than 5 microns.
2. The method of claim 1 , wherein the simulated fluid flow properties is selected from the group consisting of: distribution, residence time, hold-up volume, pressure loss, and fluid velocity.
3. The method of claim 1 , wherein the computing software used to simulate fluid flow properties is a computerized fluid dynamics (CPD) software.
4. The method of claim 1 , wherein the free form fabrication is conducted by a computer-controlled free form fabrication system.
5. The method of claim 1 , wherein the three-dimensional tortuous channel system comprises tapered channel segments.
6. The method of claim 1 , wherein the three-dimensional tortuous channel system comprises no joints and comers.
7. The method of claim 1 , wherein the three-dimensional tortuous channel system comprises two or more generations of branching.
8. The method of claim 1 , wherein the surface of the three-dimensional tortuous channel system is constructed from a material that generates less than 1 mg/l leachables in an extraction fluid.
9. The method of claim 1 , wherein the free form fabrication method is selected from the group consisting of: electron beam melting, electron beam free from fabrication, fused deposition modelling, laminated object manufacturing, laser engineered net shaping, selective laser sintering, shape deposition manufacturing, solid ground curing, stereo lithography, three-dimensional printing, and robocasting.
10. The method of claim 1 , wherein modifying the surfaces of the three-dimensional tortuous channel system comprises applying a coating on the surfaces of the three-dimensional tortuous channel system, wherein the coating comprises at least one of:
a crosslinkable oligomer;
a solution or dispersion of polymers in evaporating solvents;
a solution of metal ions; or
a hydrophilic protein-repellant coating.
11. The method of claim 1 , wherein modifying the surfaces of the three-dimensional tortuous channel system comprises abrading the surfaces of the three-dimensional tortuous channel system.