Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
The present disclosure provides compounds of Formula (IA), such as, e.g., (R)-2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-methyl-4-(4-(oxetan-3-yl)piperazin-1-yl)pent-2-enenitrile having the chemical structure and/or pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular BTK inhibitors, and are potentially useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer, inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and/or pharmaceutically acceptable salts thereof and processes for preparing such compounds and pharmaceutically acceptable salts thereof.
1. A method for treating a disease in a patient in recognized need thereof, wherein the disease is selected from the group consisting of autoimmune hepatitis, Behcet's disease, Graves' disease, multiple sclerosis, nephritis, pancreatitis, primary biliary cirrhosis, and ulcerative colitis, comprising administering to the patient in recognized need thereof a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a therapeutically effective amount of a compound selected from the group consisting of:
and/or a pharmaceutically acceptable salt and/or individual (E)-stereoisomer or (Z)-stereoisomer of any of the above compounds.
2. The method of claim 1 , wherein the disease is autoimmune hepatitis.
3. The method of claim 1 , wherein the disease is Behcet's disease.
4. The method of claim 1 , wherein the disease is Graves' disease.
5. The method of claim 1 , wherein the disease is multiple sclerosis.
6. The method of claim 1 , wherein the disease is nephritis.
7. The method of claim 1 , wherein the disease is pancreatitis.
8. The method of claim 1 , wherein the disease is primary biliary cirrhosis.
9. The method of claim 1 , wherein the disease is ulcerative colitis.
10. A method for treating a disease in a patient in recognized need thereof, wherein the disease is selected from the group consisting of autoimmune hepatitis, Behcet's disease, Graves' disease, multiple sclerosis, nephritis, pancreatitis, primary biliary cirrhosis, and ulcerative colitis, comprising administering to the patient in recognized need thereof a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a therapeutically effective amount of:
and/or a pharmaceutically acceptable salt thereof.
11. The method of claim 10 , wherein the disease is autoimmune hepatitis.
12. The method of claim 10 , wherein the disease is Behcet's disease.
13. The method of claim 10 , wherein the disease is Graves' disease.
14. The method of claim 10 , wherein the disease is multiple sclerosis.
15. The method of claim 10 , wherein the disease is nephritis.
16. The method of claim 10 , wherein the disease is pancreatitis.
17. The method of claim 10 , wherein the disease is primary biliary cirrhosis.
18. The method of claim 10 , wherein the disease is ulcerative colitis.