IP Library Granted Patent US 10,987,331
Granted Patent B2
US 10,987,331 · App. 16/709,492 · Granted Apr 27, 2021

Methods of treating mixed dyslipidemia

Inventors: Ian Osterloh (Kent, GB); Pierre Wicker (Mystic, CT); Rene Braeckman (Richboro, PA); Paresh Soni (Mystic, CT); Mehar Manku (Birmingham, GB)
Assignee: Amarin Pharmaceuticals Ireland Limited
A61K31/202A61K9/48A61K31/222A61K31/232A61K31/40A61K31/505A61K45/06A61K47/22A61K47/26A61K47/34A61K31/74A61P3/06
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Quick Facts
Patent No.
US 10,987,331
App. No.
16/709,492
Granted
Apr 27, 2021
Kind
B2
Abstract

The present disclosure relates to, inter alia, methods of treating mixed dyslipidemia with ethyl eicosapentaenoate.

Claims (4)

1. A method of treating or preventing stroke and/or myocardial infarction in a subject on statin and anticoagulant/antiplatelet therapy and having elevated triglycerides of at least about 150 mg/dL, the method comprising coadministering to said subject about 4 g of ethyl icosapentate per day with the subject's statin and anticoagulant/antiplatelet therapy, wherein the ethyl icosapentate is present in a pharmaceutical composition and the ethyl icosapentate comprises at least about 96 wt. % of all omega-3 fatty acids in the pharmaceutical composition.

2. The method of claim 1 , wherein administering lowers triglycerides in the subject.

3. The method of claim 1 , wherein about 1 g of the pharmaceutical composition is present in each of 4 capsules.

4. The method of claim 1 , wherein the antiplatelet agent is selected from the group consisting of adeparin, aspirin, clopidogrel, danaparoid, deltaparin, denaparoid, ticlopidine, cilostazol, abciximab, eptifibatide, tirofiban, defibrotide, enoxaparin, dipyridamole, and tinzaparin.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 10, 2019
From: OSTERLOH, IAN; WICKER, PIERRE; BRAECKMAN, RENE; SONI, PARESH; MANKU, MEHAR
To: AMARIN PHARMACEUTICALS IRELAND LIMITED
Reel/Frame 051236/0507 →
Cited By (2)
US 12,246,003 US 12,427,134