Treatment of osteoarthritis
Provided are compositions and methods for treating osteoarthritis including intra-articular administration of a compound of Formula (I) including amorphous and polymorph forms thereof.
1. A composition comprising a polymorph of a compound of Formula (I):
wherein the polymorph is Form 1 and has an X-ray powder diffraction pattern comprising peaks at ° 2θ values of 6.8±0.2, 12.4±0.2, and 18.5±0.2; and
wherein less than about 20% by weight of the amount of the compound of Formula (I) in the composition is polymorph Form 9 having X-ray powder diffraction pattern comprising peaks at ° 2θ values of 4.9±0.2, 18.6±0.2, and 21.1±0.2.
2. The composition of claim 1 , wherein Form 1 has an X-ray powder diffraction pattern comprising peaks at ° 2θ values of 6.8±0.2, 12.4±0.2, 16.5±0.2, 18.5±0.2, and 19.2±0.2.
3. The composition of claim 2 , wherein Form 1 has an X-ray powder diffraction pattern comprising peaks at ° 2θ values of 6.8±0.2, 9.3±0.2, 12.4±0.2, 13.9±0.2, 16.5±0.2, 18.5±0.2, 19.2±0.2, and 24.6±0.2.
4. The composition of claim 3 , wherein Form 1 has an X-ray powder diffraction pattern comprising peaks at ° 2θ values of 6.8±0.2, 9.3±0.2, 12.4±0.2, 13.9±0.2, 14.5±0.2, 16.5±0.2, 18.5±0.2, 19.2±0.2, 20.3±0.2, and 24.6±0.2.
5. The composition of claim 1 wherein Form 1 has a DSC curve comprising an endotherm from about 50° C. to about 100° C.
6. The composition of claim 1 , wherein Form 1 has a DSC curve comprising an exotherm from about 279° C. to about 281° C.
7. The composition of claim 1 , wherein less than 5% by weight of the amount of the compound of Formula (I) in the composition is polymorph Form 9.
8. The composition of claim 7 , wherein the composition is substantially free of Form 9 of the compound of Formula (I).
9. The composition of claim 8 , wherein the composition is substantially free of other anhydrous forms of the compound of Formula I.
10. A composition comprising a polymorph of a compound of Formula (I):
wherein the polymorph is a non-stoichiometric hydrate of Form 1 having between 1% and about 20% by weight water; and wherein less than about 20% by weight of the amount of the compound of Formula (I) in the composition is polymorph Form 9 having X-ray powder diffraction pattern comprising peaks at ° 2θ values of 4.9±0.2, 18.6±0.2, and 21.1±0.2.
11. The composition of claim 10 , wherein less than 5% by weight of the amount of the compound of Formula (I) in the composition is polymorph Form 9.
12. The composition of claim 11 , wherein the composition is substantially free of Form 9 of the compound of Formula (I).
13. The composition of claim 12 , wherein the composition is substantially free of other anhydrous forms of the compound of Formula (I).
14. The composition of claim 13 , wherein the composition is substantially free of any form of the compound of Formula (I) other than Form 1 and the non-stoichiometric hydrate.
15. A composition comprising a mixture of polymorphs of a compound of Formula (I):
wherein the mixture comprises a polymorph Form 1 having an X-ray powder diffraction pattern comprising peaks at ° 2θ values of 6.8±0.2, 12.4±0.2, and 18.5±0.2; and a non-stoichiometric hydrate of Form I having between 1% and about 20% by weight water; and
wherein less than about 20% by weight of the amount of the compound of Formula (I) in the composition is polymorph Form 9 having X-ray powder diffraction pattern comprising peaks at ° 2θ values of 4.9±0.2, 18.6±0.2, and 21.1±0.2.
16. The composition of claim 15 , wherein the composition is substantially free of other anhydrous forms of the compound of Formula (I).
17. The composition of claim 16 , wherein the composition is substantially free of any form of the compound of Formula (I) other than Form 1.
18. The composition of claim 17 , wherein the composition is substantially free of any form of the compound of Formula (I) other than Form 1 and the non-stoichiometric hydrate of Form I.
19. The composition of claim 15 , wherein the composition is substantially free of Form 9 of the compound of Formula I.
20. A pharmaceutical composition comprising a compound of Formula (I):
wherein the compound of Formula (I) is substantially present as a non-stoichiometric hydrate of Form 1 having between 1% and about 20% by weight water; and a pharmaceutically acceptable carrier; wherein less than about 20% by weight of the amount of the compound of Formula (I) in the composition is polymorph Form 9 having X-ray powder diffraction pattern comprising peaks at ° 2θ values of 4.9±0.2, 18.6±0.2, and 21.1±0.2.
21. The pharmaceutical composition of claim 20 , wherein the composition further comprises the amorphous form of the compound of Formula (I).
22. The pharmaceutical composition of claim 20 , wherein the composition further comprises a polymorph Form 1 having an X-ray powder diffraction pattern comprising peaks at ° 2θ values of 6.8±0.2, 12.4±0.2, and 18.5±0.2.
23. The pharmaceutical composition of claim 20 , wherein the compound of Formula (I) is present in a therapeutically effective amount.
24. The pharmaceutical composition of claim 23 , wherein the therapeutically effective amount is about 1 μg, 5 μg, 10 μg, 30 μg, 50 μg, 70 μg, 100 μg, 230 μg, 250 μg, 500 μg, 750 μg, 1000 μg, 1500 μg, 2000 μg, 2500 μg, 3000 μg, 3500 μg, 4000 μg, or 5000 μg.
25. A pharmaceutical composition prepared by a process comprising mixing a pharmaceutically acceptable carrier and one or more polymorphs of a compound of Formula (I):
wherein the polymorphs are selected from the group consisting of a polymorph Form 1 having an X-ray powder diffraction pattern comprising peaks at ° 2θ values of 6.8±0.2, 12.4±0.2, and 18.5±0.2; a non-stoichiometric hydrate of Form 1 having between 1% and about 20% by weight water; and mixtures thereof;
wherein less than about 20% by weight of the amount of the compound of Formula (I) is polymorph Form 9 having X-ray powder diffraction pattern comprising peaks at ° 2θ values of 4.9±0.2, 18.6±0.2, and 21.1±0.2.
26. The pharmaceutical composition of claim 25 , wherein the process comprises mixing a therapeutically effective amount of Form 1 and the pharmaceutically acceptable carrier.
27. The pharmaceutical composition of claim 25 , wherein the process comprises mixing a therapeutically effective amount of a non-stoichiometric hydrate of Form 1 having between 1% and about 20% by weight water, and the pharmaceutically acceptable carrier.
28. The pharmaceutical composition of claim 25 , wherein the process comprises mixing Form 1, a non-stoichiometric hydrate of Form 1 having between 1% and about 20% by weight water, and the pharmaceutically acceptable carrier, and the sum of the amounts of Form 1 and the non-stoichiometric hydrate of Form 1 is a therapeutically effective amount.
29. The pharmaceutical composition of claim 25 , wherein the composition comprises a buffer and an excipient.
30. The pharmaceutical composition of claim 29 , wherein the excipient comprises a surfactant, a cellulose derivative, or a mixture thereof.
31. The pharmaceutical composition of claim 30 , wherein the cellulose derivative is a water-soluble cellulose derivative.
32. The pharmaceutical composition of claim 30 , wherein the surfactant is a polysorbate.
33. The pharmaceutical composition of claim 31 , wherein the cellulose derivative is sodium carboxymethylcellulose.
34. The pharmaceutical composition of claim 30 , wherein the composition comprises about 0.1% to about 1% by weight of a cellulose derivative; and about 0.1% to about 0.1% by weight of a surfactant.
35. The pharmaceutical composition of claim 29 , wherein the buffer is phosphate buffered saline.
36. The pharmaceutical composition of claim 30 , wherein the composition comprises about 0.5% sodium carboxymethylcellulose by weight and about 0.05% polysorbate 80 by weight in phosphate buffered saline.
37. The pharmaceutical composition of claim 30 , wherein the composition comprises about 0.005 mg/mL to about 2.5 mg/mL, about 0.01 mg/mL to about 2.0 mg/mL, about 0.01 mg/mL to about 1 mg/mL, about 0.01 mg/mL to about 0.5 mg/mL, about 0.01 mg/mL to about 0.2 mg/mL, or about 0.015 mg/mL to about 0.115 mg/mL of the compound of Formula (I).
38. The pharmaceutical composition of claim 37 , wherein the composition comprises about 0.015 mg/mL to about 0.115 mg/mL of the compound of Formula (I).
39. The pharmaceutical composition of claim 30 , wherein the composition comprises about between about 0.001 mg and about 1 mg, about 0.03 mg and about 0.5 mg, about 0.03 mg and about 0.23 mg, about 0.05 mg and about 0.2 mg, about 0.1 mg and about 0.2 mg of the compound of Formula (I).
40. The pharmaceutical composition of claim 30 , wherein the composition is a suspension.
41. The pharmaceutical composition of claim 40 , wherein the composition comprises particles of a compound of Formula (I) having a median size of less than 20 μm.
42. The pharmaceutical composition of claim 41 , wherein the composition comprises particles having a D50 of between about 1 μm and about 6 μm.
43. The pharmaceutical composition of claim 30 , wherein the pH of the composition is from about 6.5 to about 8.5.
44. The pharmaceutical composition of claim 30 , wherein the composition is stable for at least three months when stored at 30° C. and 65% relative humidity.
45. The pharmaceutical composition of claim 40 , wherein the administration is intraarticular administration.
46. The pharmaceutical composition of claim 45 , wherein the formulation comprises 250 μg of the compound of Formula (I); and wherein the concentration of the compound of Formula (I) in the plasma is less than about 0.1 μg/mL when measured 4 hours after administration of the composition to a subject.
47. A polymorph of a compound of Formula (I):
wherein the polymorph is Form 9 and has an X-ray powder diffraction pattern comprising peaks at ° 2θ values of 4.9±0.2, 18.6±0.2, and 21.1±0.2.
48. The polymorph of claim 47 , wherein Form 9 has an X-ray powder diffraction pattern comprising peaks at ° 2θ values of 4.9±0.2, 18.6±0.2, 21.1±0.2, 24.1±0.2, and 25.2±0.2.
49. The polymorph of claim 48 , wherein Form 9 has an X-ray powder diffraction pattern comprising peaks at ° 2θ values of 4.9±0.2, 10.1±0.2, 15.3±0.2, 16.5±0.2, 18.6±0.2, 21.1±0.2, 22.4±0.2, 24.1±0.2, 25.2±0.2, and 28.6±0.2.
50. The polymorph of claim 49 , wherein Form 9 has a DSC curve comprising an exotherm at about 364° C.