ANTI SEZ6 ANTIBODIES AND METHODS OF USE
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
1 .- 20 . (canceled)
21 . A monoclonal antibody that comprises or competes for binding to a human SEZ6 protein with an antibody comprising a light chain variable region comprising an amino acid sequence set forth as SEQ ID NO: 190 and a heavy chain variable region comprising an amino acid sequence set forth as SEQ ID NO: 191.
22 . The monoclonal antibody according to claim 21 , wherein said antibody is an internalizing antibody.
23 . The monoclonal antibody according to claim 21 , wherein the antibody comprises a chimeric antibody, a CDR grafted antibody, or a humanized antibody.
24 . The monoclonal antibody according to claim 22 , wherein the antibody comprises a chimeric antibody, a CDR grafted antibody, or a humanized antibody.