Compositions comprising bacterial strains
The invention provides compositions comprising bacterial strains for treating and preventing a neurodegenerative disorder.
1. A method of treating a neurodegenerative disorder in a human subject in need thereof, comprising
administering to the human subject a pharmaceutical composition consisting essentially of a single bacteria strain in an amount of 1×10 6 to 1×10 11 CFU/g with respect to a total weight of the pharmaceutical composition,
wherein the neurodegenerative disorder is Parkinson's disease or Alzheimer's disease, and wherein the single bacteria strain is Parabacteroides distasonis having a 16S rRNA gene sequence of SEQ ID NO: 9.
2. The method of claim 1 , wherein the neurodegenerative disorder is an early-onset neurodegenerative disease.
3. The method of claim 1 , wherein the method is a method of delaying an onset or a progression of the neurodegenerative disorder.
4. The method of claim 1 , wherein the pharmaceutical composition is formulated for oral administration.
5. The method of claim 1 , wherein the pharmaceutical composition comprises one or more pharmaceutically acceptable excipients or carriers.
6. The method of claim 1 , wherein the single bacteria strain is lyophilized.
7. The method of claim 6 , wherein the lyophilized bacteria strain is live.
8. The method of claim 1 , wherein the neurodegenerative disorder is Alzheimer's disease.
9. The method of claim 1 , wherein the only bacteria in the pharmaceutical composition is the single bacteria strain.