Stent including anti-migration capabilities
An example medical device for treating a body lumen is disclosed. The medical device includes an expandable scaffold including first and second regions, each of the first and second regions include a plurality of interstices located therein. The medical device also includes a covering spanning each of the plurality of interstices of the first region. The second region is free of the covering. A biodegradable gripping material is disposed on an outer surface of the covering. Further, the expandable scaffold is configured to shift from a collapsed state to an expanded state and the second region is configured to contact an inner surface of the body lumen in the expanded state. Additionally, the gripping material is designed to initially prevent migration of the expandable scaffold upon implantation in the body lumen until the second region is secured to the inner surface of the body lumen.
1. A medical device for treating a body lumen, comprising:
an expandable scaffold including a first region and a second region, each of the first and second regions including a plurality of interstices located therein;
a covering spanning at least a portion of the plurality of interstices of the first region, wherein the covering is formed of a biostable material; and
a gripping material disposed on at least a portion of the outer surface of the covering, wherein the gripping material is biodegradable and has a roughened surface with a surface roughness value of about 0.5 micrometers (μm) to about 2.5 μm.
2. The medical device of claim 1 , wherein the second region is devoid of the covering.
3. The medical device of claim 2 , wherein the expandable scaffold is configured to shift from a collapsed state to an expanded state, and when in the expanded state, the gripping material is designed to initially prevent migration of the expandable scaffold in the body lumen until at least a portion of the second region is secured to the inner surface of the body lumen via tissue ingrowth into the interstices of the second region.
4. The medical device of claim 3 , wherein the gripping material is configured to degrade over a first time period.
5. The medical device of claim 4 , wherein the securement of the second region to the inner surface of the body lumen occurs over a second time period.
6. The medical device of claim 5 , wherein the second time period occurs before the first time period.
7. The medical device of claim 5 , wherein the second time period overlaps with the first time period.
8. The medical device of claim 7 , wherein the second time period is between 4 to 18 days.
9. The medical device of claim 2 , further comprising a third region positioned on an end of the scaffold opposite the second region, wherein the third region is devoid of the covering.
10. The medical device of claim 2 , wherein the second region includes an endothelializing material disposed along a surface thereof.
11. The medical device of claim 1 , wherein the covering is configured to provide a pathway for food to travel therethrough.
12. The medical device of claim 1 , wherein the expandable scaffold has a longitudinal axis and a length along the longitudinal axis and wherein the second region has a length which is between 5-15% of the length of the expandable scaffold.
13. The medical device of claim 1 , wherein the second region includes a flared portion.
14. A medical device for treating a body lumen, comprising:
an expandable scaffold including a first region and a second region, each of the first and second regions including a plurality of struts defining a plurality of interstices located therebetween;
a covering spanning at least a portion of the plurality of interstices of the first region, wherein the covering is biostable; and
a gripping material disposed on at least a portion of the outer surface of the covering, wherein the gripping material is biodegradable and has a roughened surface with a surface roughness value of about 0.5 micrometers (μm) to about 2.5 μm;
wherein the expandable scaffold is configured to shift from a collapsed state to an expanded state, and wherein the second region is configured to contact an inner surface of the body lumen in the expanded state;
wherein the struts of the second region are configured to be secured to the inner surface of the body lumen via tissue ingrowth into the interstices of the second region;
wherein the gripping material is designed to initially prevent migration of the expandable scaffold upon implantation in the body lumen until the second region is secured to the inner surface of the body lumen.
15. The medical device of claim 14 , wherein the struts of the second region are bare metal.
16. The medical device of claim 14 , wherein the gripping material is configured to degrade over a first time period.
17. The medical device of claim 16 , wherein the securement of the second region to the inner surface of the body lumen occurs over a second time period.
18. The medical device of claim 17 , wherein the second time period occurs before the first time period.
19. The medical device of claim 17 , wherein the second time period overlaps with the first time period.
20. A method for treating an intestine, the method comprising:
advancing an expandable scaffold to a target site within the intestine, the expandable scaffold including:
a first region and a second region, each of the first and second regions including a plurality of interstices located therein;
a covering spanning at least a portion of the plurality of interstices of the first region, and wherein the covering is formed of a biostable material; and
a gripping material disposed on at least a portion of the outer surface of the covering, wherein the gripping material is biodegradable and has a roughened surface with a surface roughness value of about 0.5 micrometers (μm) to about 2.5 μm;
radially expanding the scaffold from the contracted state to the expanded state such that the second region is configured to contact an inner surface of the intestine in the expanded state;
temporarily securing the inner surface of the first region to the inner surface of the intestine with the gripping material until the second region is secured to the inner surface of the intestine via tissue ingrowth into the interstices of the second region.