METHODS FOR TREATING VASCULAR LEAK SYNDROME
Disclosed are methods for treating Vascular Leak Syndrome. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, inter alia, sepsis, lupus, irritable bowel disease. Yet further disclosed are methods for treating renal cell carcinoma and melanoma. Still further disclosed are methods for reducing metastasis of malignant cells and/or preventing the proliferation of carcinoma cells via spreading due to vascular leakage.
1 - 20 . (canceled)
21 . A method of treating a kidney condition in a subject in need thereof, the method comprising administering to the subject a therapeutically-effective amount of a Tie-2 activator.
22 . The method of claim 21 , wherein the kidney condition is acute kidney injury.
23 . The method of claim 22 , wherein the acute kidney injury is sepsis-induced acute kidney injury.
24 . The method of claim 21 , wherein the subject has an inflammatory disease.
25 . The method of claim 21 , wherein the subject is infected with a pathogen.
26 . The method of claim 21 , wherein the administering reduces a blood urine nitrogen (BUN) level in the subject.
27 . A method of treating a kidney condition in a subject in need thereof, the method comprising administering to the subject a therapeutically-effective amount of a HPTP-β inhibitor.
28 . The method of claim 27 , wherein the kidney condition is acute kidney injury.
29 . The method of claim 28 , wherein the acute kidney injury is sepsis-induced acute kidney injury.
30 . The method of claim 27 , wherein the subject has an inflammatory disease.
31 . The method of claim 27 , wherein the subject is infected with a pathogen.
32 . The method of claim 27 , wherein the administering reduces a blood urine nitrogen (BUN) level in the subject.