Ophthalmic compositions with improved dessication protection and retention
The present invention relates to artificial tear compositions and ophthalmic compositions suitable for drug delivery. In one embodiment of the present invention, the compositions comprise a galactomannan polymer such as guar or hydroxypropyl guar, hyaluronic acid, and a cis-diol such as sorbitol. In a preferred embodiment, the compositions also comprise a borate compound.
1. An ophthalmic composition comprising 0.17 to 0.18 w/v % hydroxypropyl guar, 0.15 w/v % sodium hyaluronate, and 1.4 w/v % sorbitol.
2. An ophthalmic composition according to claim 1 further comprising a borate, wherein said borate is boric acid.
3. An ophthalmic composition according to claim 1 further comprising a demulcent selected from the group consisting of: glycerin, polyvinyl pyrrolidone, polyethylene oxide, polyethylene glycol, propylene glycol, polyacrylic acid, and combinations thereof.
4. An ophthalmic composition according to claim 3 wherein said demulcent is polypropylene glycol or polyethylene glycol.
5. An ophthalmic composition according to claim 1 further comprising a pharmaceutically active compound.
6. An ophthalmic composition according to claim 1 , for use in treating ophthalmic disease.
7. An ophthalmic composition for use according to claim 6 , wherein the ophthalmic disease is dry eye.