IP Library Granted Patent US 11,419,888
Granted Patent B2
US 11,419,888 · App. 16/723,912 · Granted Aug 23, 2022

Composition and method for promoting reduction of heat stress in animals

Inventors: James D. Chapman (Macon, GA); David Calabotta (Quincy, IL); Neil E. Forsberg (Corvallis, OR); Steven B. Puntenney (Ione, OR); Robert Collier (Tucson, AZ); Laun Hall (Spanish Fork, UT)
Assignees: OmniGen Research, L.L.C.; The Arizona Board of Regents on behalf of the University of Arizona
A61K31/716A23K20/163A23K20/20A23K20/28A23K50/10A23K50/20A23K50/30A23K50/40A23K50/70A61K31/715A61K31/736A61K33/00A61K33/06A61K35/00A61K35/02A61K38/47A61K45/06
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Quick Facts
Patent No.
US 11,419,888
App. No.
16/723,912
Granted
Aug 23, 2022
Kind
B2
Abstract

Disclosed herein is a method for promoting reduction of heat stress in animals, as well as a composition for use in the disclosed method. The composition comprises a glucan, silica, mineral clay, mannan, and optionally an endoglucanohydrolase, and may be administered to an animal that is susceptible to or suffers from heat stress.

Claims (29)

1. A method, comprising:

identifying a bovine that is at risk of experiencing a heat effect;

assessing a bovine's initial water consumption, a bovine's initial respiration rate, or both the bovine's initial water consumption and the bovine's initial respiration rate; and

administering to the bovine a composition comprising between 1.0 wt % and 5.0 wt % (β-glucans, between 15 wt % and 40 wt % silica, between 50 wt % and 81 wt % mineral clay, between 1 wt % and 8.0 wt % mannan, and endoglucanohydrolase, wherein the composition is administered for an effective period of time of from 7 days to 200 days to decrease the bovine's water consumption, the bovine's respiration rate, or both the bovine's water consumption and the bovine's respiration rate during the effective period of time, when compared to the bovine's initial water consumption, the bovine's initial respiration rate, or both the bovine's initial water consumption and the bovine's initial respiration rate prior to administering the composition.

2. The method of claim 1 , wherein the bovine is a dairy cow.

3. The method of claim 2 , further comprising administering the composition to the dairy cow:

(a) for a period from 100 days prior to lactation onset to 1 day prior to lactation onset; or

(b) after lactation onset; or

(c) for 40 days to 100 days post calving; or

(d) any combination thereof.

4. The method of claim 1 , further comprising administering the composition to the bovine when a temperature humidity index is, or is expected to be, greater than 68.

5. The method of claim 1 , further comprising administering to the bovine a therapeutic process, a therapeutic agent, or a combination thereof, wherein the therapeutic process or therapeutic agent is provision of shade to the bovine, use of a water sprinkler to externally administer water to the bovine, use of a fan to provide air movement, addition of bypass fats to feed for the bovine, meloxicam, a corticosteroid, a composition comprising one or more electrolytes, an alkalinizing agent, a direct-fed microbial, or a combination thereof.

6. The method of claim 1 , further comprising:

administering the composition to individual bovines in a group of bovines for a first period of time;

subsequently evaluating water consumption, respiration rate, or both the water consumption and the respiration rate of at least one bovine of the group of bovines; and

administering an adjusted amount of the composition to the group of bovines for a subsequent period of time, wherein the adjusted amount is based at least in part on the subsequent evaluation of the water consumption, the respiration rate, or both the water consumption and the respiration rate.

7. The method of claim 1 , further comprising:

increasing an amount of the composition administered to the bovine to an increased amount if a temperature humidity index is expected to increase to 68 or greater; or

decreasing an amount of the composition administered to the bovine to a decreased amount if a temperature humidity index is expected to decrease below 68, wherein the decreased amount of the composition is at least 50 grams per head per day.

8. The method of claim 1 , wherein the effective period of time is at least 30 days, the method further comprising administering the composition at set intervals to the bovine.

9. The method of claim 8 , wherein the composition is administered daily to the bovine.

10. The method of claim 1 , wherein the composition further comprises a carbonate, kelp, niacin, vitamin B-12, biotin, d-calcium pantothenate, choline chloride, thiamine mononitrate, pyridoxine hydrochloride, menadione dimethylpyrimidinol bisulfite, riboflavin-5-phosphate, folic acid, soybean oil, calcium aluminosilicate, rice hulls, mineral oil, or any combination thereof.

11. A method, comprising:

identifying a bovine that is at risk of experiencing a heat effect and that has been administered a first amount of a composition comprising between 1.0 wt % and 5.0 wt % (β-glucans, between 15 wt % and 40 wt % silica, between 50 wt % and 81 wt % mineral clay, between 1 wt % and 8.0 wt % mannan, and endoglucanohydrolase for a time period of from 7 days to 200 days, the bovine having a first water consumption, a first respiration rate, or a first water consumption and a first respiration rate that are decreased relative to the bovine's water consumption, the bovine's respiration rate, or both the bovine's water consumption and the bovine's respiration rate prior to administering the first amount of the composition;

monitoring the bovine during a subsequent period of heat stress; and

administering to the bovine a second amount of the composition that is greater than the first amount, the second amount being sufficient to maintain or reduce the bovine's water consumption, the bovine's respiration rate, or both the bovine's water consumption and the bovine's respiration rate, such that the bovine's water consumption, the bovine's respiration rate, or both the bovine's water consumption and the bovine's respiration rate subsequent to administration of the second amount are substantially the same as the first water consumption, the first respiration rate, or both the first water consumption and the first respiration rate.

12. The method of claim 11 , wherein the first amount is at least 50 grams per head per day and the second amount is greater than the first amount and up to 70 grams per head per day.

13. The method of claim 1 , wherein the composition is administered to the bovine for an effective period of time to decrease water consumption during the effective period of time, when compared to the bovine's water consumption prior to administering the composition.

14. The method of claim 1 , wherein the composition is administered to the bovine for an effective period of time to decrease the bovine's respiratory rate during the effective period of time, when compared to the bovine's respiratory rate prior to administering the composition.

Assignments (5)
RELEASE OF SECURITY INTEREST IN PATENTS AT REEL 056139, FRAME 0578 Recorded Jul 17, 2024
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: PHIBRO ANIMAL HEALTH CORPORATION; OMNIGEN RESEARCH, LLC
Reel/Frame 068404/0557 →
SECURITY INTEREST Recorded Jul 15, 2024
From: PHIBRO ANIMAL HEALTH CORPORATION; PRINCE AGRI PRODUCTS, INC.; OMNIGEN RESEARCH, LLC
To: COÖPERATIEVE RABOBANK U.A., NEW YORK BRANCH, AS COLLATERAL AGENT
Reel/Frame 068370/0043 →
SECURITY INTEREST Recorded May 5, 2021
From: PHIBRO ANIMAL HEALTH CORPORATION; OMNIGEN RESEARCH, LLC
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 056139/0578 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 11, 2020
From: CHAPMAN, JAMES D.; CALABOTTA, DAVID; FORSBERG, NEIL E.; PUNTENNEY, STEVEN B.
To: OMNIGEN RESEARCH, L.L.C.
Reel/Frame 051789/0418 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 11, 2020
From: COLLIER, ROBERT; HALL, LAUN
To: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
Reel/Frame 051789/0443 →