IP Library Granted Patent US 10,919,902
Granted Patent B2
US 10,919,902 · App. 16/726,990 · Granted Feb 16, 2021

Hetero-halo inhibitors of histone deacetylase

Inventors: Martin R. Jefson (Stonington, CT); John A. Lowe, III (Stonington, CT); Fabian Dey (Basel, CH); Andreas Bergmann (Gauting, DE); Andreas Schoop (Grafrath, DE); Nathan Oliver Fuller (Arlington, MA)
Assignee: Alkermes, Inc.
C07D487/04A61K31/13A61K31/167A61K31/27A61K31/351A61K31/40A61K31/415A61K31/4155A61K31/4192A61K31/421A61K31/426A61K31/427A61K31/435A61K31/437A61K31/44A61K31/444A61K31/445A61K31/4433A61K31/4439A61K31/496A61K31/4965A61K31/4985A61K31/50A61K31/505A61K31/506A61K31/5377A61K31/55A61K45/06C07D207/06C07D309/14C07D401/12C07D401/14C07D403/12C07D405/12C07D409/12C07D413/14C07D417/12C07D417/14C07D471/10C07D487/10C07D491/107C07D513/04
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Quick Facts
Patent No.
US 10,919,902
App. No.
16/726,990
Granted
Feb 16, 2021
Kind
B2
Abstract

This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.

Claims (2)

1. A compound having the formula:

or a pharmaceutically acceptable salt thereof.

Assignments (5)
SECURITY INTEREST Recorded Feb 13, 2026
From: ALKERMES, INC.
To: JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT
Reel/Frame 073790/0950 →
RELEASE OF SECURITY INTEREST IN PATENTS PREVIOUSLY RECORDED AT REEL/FRAME (072656/0509) Recorded Feb 13, 2026
From: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
To: ALKERMES, INC.
Reel/Frame 074858/0481 →
SECURITY INTEREST Recorded Oct 23, 2025
From: ALKERMES, INC.
To: JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT
Reel/Frame 072656/0509 →
CHANGE OF NAME Recorded Dec 1, 2020
From: RODIN THERAPEUTICS, INC.
To: ALKERMES, INC.
Reel/Frame 054504/0354 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 27, 2020
From: JEFSON, MARTIN R.; LOWE, JOHN A., III; DEY, FABIAN; BERGMANN, ANDREAS; SCHOOP, ANDREAS; FULLER, NATHAN OLIVER
To: RODIN THERAPEUTICS, INC.
Reel/Frame 051627/0788 →