ANTITHROMBOGENIC HOLLOW FIBER MEMBRANES AND FILTERS
The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.
1 . A hollow fiber membrane, said hollow fiber membrane comprising a base polymer admixed with from 0.005% to 10% (w/w) surface modifying macromolecule, wherein said hollow fiber membrane is antithrombogenic when contacted with blood.
2 . The hollow fiber membrane of claim 2 , wherein the thrombi deposition on said surface said hollow fiber membrane is reduced by at least 10% when contacted with blood, wherein said hollow fiber membrane has an operating pressure after 4 hours of use that is reduced by at least 10%, or wherein said hollow fiber membrane reduces adverse advents in a subject receiving blood passing through said hollow fiber membrane.
3 . The hollow fiber membrane of claim 2 , wherein said base polymer is selected from the group consisting of a polysulfone, a polyacrylonitrile, a cellulose acetate, a cellulose di- or tri-acetate, a polyimide, a poly(methyl methacrylate), a polycarbonate, a polyamide, a polypropylene, and a polyethylene.
4 . The hollow fiber membrane of claim 3 , wherein said base polymer is a polysulfone selected poly(oxy-1,4-phenylene sulfonyl-1,4-phenyleneoxy-1,4-phenyleneisopropylidene-1,4-phenylene) or polyether sulfone.
5 . The hollow fiber membrane of claim 1 , further comprising a hydrophilic pore forming agent.
6 . The hollow fiber membrane of claim 5 , wherein said hydrophilic pore forming agent is selected from polyvinylpyrrolidone, ethylene glycol, alcohols, polypropylene glycol, and polyethylene glycol, or mixtures thereof.
7 . The hollow fiber membrane of claim 5 , comprising from 80% to 96.5% (w/w) of said base polymer, from 3% to 20% (w/w) of said hydrophilic pore forming agent, and 0.005% to 10% (w/w) of said surface modifying macromolecule.
8 . The hollow fiber membrane of claim 1 , wherein said surface modifying macromolecule is selected from VII-a, VIII-a, VIII-b, VIII-c, VIII-d, IX-a, X-a, X-b, XI-a, XI-b, XII-a, XII-b, XIII-a, XIII-b, XIII-c, XIII-d, XIV-a, and XIV-b.