Microcell systems for delivering active molecules
An active molecule delivery system whereby active molecules can be released on demand and/or a variety of different active molecules can be delivered from the same system and/or different concentrations of active molecules can be delivered from the same system. The active delivery system includes a plurality of microcells, wherein the microcells are filled with a medium including active molecules. The microcells include an opening, and the opening is spanned by a porous diffusion layer. The microcell arrays may be loaded with different active ingredients, thereby providing a mechanism to deliver different, or complimentary, active ingredients on demand.
1. An active molecule delivery system comprising:
a plurality of microcells, each microcell including a floor and walls creating an opening, having a total thickness between 25 and 50 μm, containing a mixture comprising an active molecule, and the opening of each microcell being sealed with a sealing layer having a thickness between 0.5 μm and 8 μm;
a microneedle array comprising a plurality of microneedles at least 50 μm in length, wherein the plurality of microneedles is formed from polymers, metal, semiconductors or combinations thereof; and
a compressible layer disposed between the microneedle array and the plurality of microcells, wherein the microneedles are configured to penetrate through a microcell, thereby piercing the sealing layer and releasing the active molecule from the microcell.
2. The active molecule delivery system of claim 1 , wherein the plurality of microneedles is formed with contact printing, grown with epitaxy, built up with photolithography, or deposited with ion beam deposition.
3. The active molecule delivery system of claim 1 , wherein the plurality of microneedles are solid.
4. The active molecule delivery system of claim 1 , wherein the plurality of microneedles are hollow.
5. The active molecule delivery system of claim 1 , wherein the plurality of microneedles comprise openings.
6. The active molecule delivery system of claim 5 , wherein the openings allow the active molecules to pass from the side of the microneedles into the lumen of the needles and out the tip into the surface to which the delivery system is attached.
7. The active molecule delivery system of claim 1 , wherein the compressible layer comprises a compressible material comprising a gel or a foam.
8. The active molecule delivery system of claim 7 , wherein the gel or foam comprises a polymer.
9. The active molecule delivery system of claim 8 , wherein polymer is polyethylene.
10. The active molecule delivery system of claim 1 , wherein the compressible layer comprises a compressible material comprising a gas-filled bladder.
11. The active molecule delivery system of claim 10 , wherein the gas-filled bladder deforms or folds as pressure is applied against the back of the microcell assembly.
12. The active molecule delivery system of claim 1 , wherein the compressible layer and the plurality of microcells are covered by an encapsulating backing.
13. The active molecule delivery system of claim 12 , wherein the encapsulating backing comprises an elastomeric material.
14. The active molecule delivery system of claim 1 , wherein the sealing layer is porous.
15. The active molecule delivery system of claim 1 , wherein the sealing layer is nonporous.
16. The active molecule delivery system of claim 1 , wherein the sealing layer comprises an acrylate, a methacrylate, a polycarbonate, a polyvinyl alcohol, cellulose, poly(N-isopropylacrylamide) (PNIPAAm), poly(lactic-co-glycolic acid) (PLGA), polyvinylidene chloride, acrylonitrile, amorphous nylon, oriented polyester, terephthalate, polyvinyl chloride, polyethylene, polypropylene, polybutylene, polyisobutylene, polystyrene, polyvinylpyrrolidone, hydroxymethylcellulose, or mixtures thereof.
17. The active molecule delivery system of claim 1 , wherein the plurality of microcells, includes first and second microcells, wherein the first microcell includes a first active molecule, and the second microcell includes a second active molecule different from the first active molecule.
18. The active molecule delivery system of claim 1 , wherein the active molecule is distributed in a biocompatible non-polar liquid or in an aqueous liquid.
19. The active molecule delivery system of claim 1 , wherein the microcell is formed from multifunctional acrylates or methacrylates.