IP Library › Granted Patent US 11,530,237
Granted Patent B2
US 11,530,237 · App. 16/748,117 · Granted Dec 20, 2022

Compositions and methods for treating CNS disorders

Inventors: Gabriel Martinez Botella (Wayland, MA); Francesco G. Salituro (Marlborough, MA); Albert Jean Robichaud (Boston, MA); Boyd L. Harrison (Princeton Junction, NJ)
Assignee: Sage Therapeutics, Inc.
C07J43/003A61K31/575A61K31/58A61K45/06C07J9/00C07J1/0011C07J1/0022C07J3/005C07J5/0053C07J7/002C07J7/007C07J7/008C07J11/00C07J13/007C07J21/00C07J31/006C07J41/0066C07J51/00C07J71/001
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Quick Facts
Patent No.
US 11,530,237
App. No.
16/748,117
Granted
Dec 20, 2022
Kind
B2
Abstract

Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein , A, R 1 , R 2 , R 3a , R 4a , R 4b , R 5 , R 7a , and R 7b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

Claims (8)

1. A compound of the formula

2. A pharmaceutically acceptable salt of a compound of the formula

3. A pharmaceutical composition comprising a compound of the formula

and

a pharmaceutically acceptable excipient.

4. A pharmaceutical composition comprising a pharmaceutically acceptable salt of a compound of the formula

and

a pharmaceutically acceptable excipient.

Assignments (2)
CHANGE OF NAME Recorded Apr 23, 2026
From: SAGE THERAPEUTICS, INC.
To: SAGE THERAPEUTICS, LLC
Reel/Frame 075472/0569 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 10, 2022
From: BOTELLA, GABRIEL MARTINEZ; SALITURO, FRANCESCO G.; ROBICHAUD, ALBERT JEAN; HARRISON, BOYD L.
To: SAGE THERAPEUTICS, INC.
Reel/Frame 058972/0827 →
Cited By (4)
US 12,358,942 US 12,473,327 US 12,534,495 US 12,655,175