Process for converting S-enantiomer to its racemic form
The present invention relates to a novel process for converting the unwanted S enantiomer form to its useful raceme with respect to a 4-aminoindane derivative and to novel intermediates of said process.
1. A compound of Formula IV,
wherein, R is selected from a C 1 -C 6 alkyl group or a C 6 -C 10 aryl group, these groups being optionally substituted with one or more of C 1 -C 6 alkyl groups and/or halogen atoms.
2. The compound of claim 1 , which is (R)-N-(7-fluoro-1,1,3-trimethyl-3-hydroxy-1H-indan-4-yl)acetamide.
3. The compound of claim 1 prepared by a process starting from Formula (II), which is (S)-7-fluoro-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-amine,
and comprising the steps of:
(a) acylating the (S)-7-fluoro-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-amine to obtain an indaneamide derivative; and
(b) oxidizing said indaneamide derivative to obtain 3-hydroxyl indaneamide derivative.
4. The compound of claim 3 which is (R)-N-(7-fluoro-1,1,3-trimethyl-3-hydroxy-1H-indan-4-yl)acetamide.