Immunomodulator compounds
Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1 , R 2a , R 2b , R 2c , R 3 , R 4 , R 5 , R 6a , R 6b , m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
1. A method of inhibiting growth, proliferation, or metastasis of cancer cells in a subject in need thereof, wherein the cancer cells are selected from the group consisting of colorectal cancer, mesothelioma; breast cancer, colorectal cancer, carcinoma of the endometrium, cancer of the esophagus, small cell lung cancer, renal cell carcinoma, Merkel cell carcinoma, hepatocellular carcinoma, primary mediastinal large B cell lymphoma; carcinoma of the cervix, gastric cancer, cancer of the bladder, classical Hodgkin's lymphoma, head and neck squamous cell carcinoma, and non-small cell lung cancer, comprising administering to the subject a therapeutically effective amount of a compound selected from the group consisting of
2. The method of claim 1 , wherein the compound is selected from the group consisting of
or a pharmaceutically acceptable salt thereof.
3. The method of claim 1 , wherein the compound has the formula:
or a pharmaceutically acceptable salt thereof.
4. The method of claim 1 , wherein the compound has the formula:
or a pharmaceutically acceptable salt thereof.
5. The method of claim 1 , wherein the compound has the formula:
or a pharmaceutically acceptable salt thereof.
6. The method of claim 1 , wherein the compound has the formula:
or a pharmaceutically acceptable salt thereof.