Compounds and uses thereof
The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.
1. A compound of formula (III-D-1):
wherein:
o is 2;
C 1 and C 2 optionally combine to form a bond;
each of R 1 , R 2 , and R 6 is, independently, H or optionally substituted C 1-6 alkyl;
R 3 is halo;
R 4 is H, OR 6 , optionally substituted C 1-6 alkyl, or halo;
L 1 is optionally substituted C 5-10 heteroaryl or —C(O)—X 5 —;
X 5 is NH, O, or optionally substituted C 1-6 alkyl; and
L 2 is O;
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising a compound, or pharmaceutically acceptable salt thereof, of claim 1 , and a pharmaceutically acceptable excipient.
3. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
5. The compound of claim 1 , wherein R 2 is H.
6. The compound of claim 1 , wherein R 4 is H.
7. The compound of claim 1 , wherein R 1 is methyl.
8. The compound of claim 1 , wherein L 1 is
9. The compound of claim 8 , wherein R 4 is H.
or a pharmaceutically acceptable salt thereof.
10. The compound of claim 3 , wherein the compound is:
11. The compound of claim 3 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
12. The compound of claim 3 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
13. The compound of claim 3 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
14. The compound of claim 3 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
15. The compound of claim 3 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
16. The compound of claim 3 , wherein the compound is
17. The compound of claim 3 , wherein the compound is
18. The compound of claim 3 , wherein the compound is
19. The compound of claim 3 , wherein the compound is
20. The compound of claim 3 , wherein the compound is
21. The compound of claim 3 , wherein the compound is
22. The compound of claim 3 , wherein the compound is