Compounds and uses thereof
The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.
1. A compound, or pharmaceutically acceptable salt thereof, having the structure of any one of the following compounds:
#
Structure
1241
1238
1237
1236
1232
1231
1228
1227
1226
1225
1110
1111
2. A pharmaceutical composition comprising a compound, or pharmaceutically acceptable salt thereof, of claim 1 , and a pharmaceutically acceptable excipient.
3. A method of alleviating the symptoms associated with a neurological disorder in a subject in need thereof, the method comprising administering an effective amount of a compound, or pharmaceutically acceptable salt thereof, of claim 1 .
4. A method of inhibiting toxicity in a cell related to a protein, the method comprising administering an effective amount of a compound, or pharmaceutically acceptable salt thereof, of claim 1 .
5. The method of claim 4 , wherein the toxicity is α-synuclein -related toxicity.
6. The method of claim 4 , wherein the toxicity is ApoE4-related toxicity.
7. The method of claim 4 , wherein the cell is a mammalian neural cell.
8. A method of alleviating the symptoms associated with a stearoyl-CoA desaturase (SCD)-associated disorder in a subject in need thereof, the method comprising administering an effective amount of a compound, or pharmaceutically acceptable salt thereof, of claim 1 .