Cannabinoid compositions and methods of use thereof
Embodiments relate to a method for treatment of a sleep disorder and to compositions comprising tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol (CBN), wherein the ratio of THC:CBD:CBN by weight is A:B:C where A is between 0.0001 and 1, B is 1, and C is between 0.05 and 1. Optionally A is between 0.001 and 0.02, B is 1 and C is between 0.2 and 0.7.
1. A method for treatment of a sleep disorder, the method comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a tetrahydrocannabinol (THC), a cannabidiol (CBD), and a cannabinol (CBN), wherein the ratio of THC:CBD:CBN by weight is A:B:C where A is between 0.0001 and 1, B is 1, and C is between 0.05 and 1.
2. The method according to claim 1 wherein A is between 0.001 and 0.02, B is 1 and C is between 0.2 and 0.7.
3. The method according to claim 2 wherein A is between 0.00125 and 0.0125, B is 1 an C is between 0.25 and 0.5.
4. The method according to claim 3 wherein A is 0.0025.
5. The method according to claim 3 wherein A is 0.00125.
6. The method according to claim 1 wherein C is 0.25.
7. The method according to claim 1 wherein C is 0.5.
8. The method according to claim 1 wherein C is 0.375.
9. The method according to claim 1 wherein the sleep disorder is selected from the group consisting of: decreased sleep duration, prolonged sleep onset, increased number of transient awakenings during a sleep session, aberrant sleep-awake cycles, aberrant sleep architecture, parasomnia, and insomnia.
10. The method according to claim 1 wherein the composition is free of terpenes.
11. The method according to claim 1 wherein the composition comprises a whole plant extract.
12. The method according to claim 1 wherein the composition is administered through the pulmonary, nasal, oral, or oral cavity route.
13. The method according to claim 1 wherein the composition is administered once daily.
14. The method according to claim 1 wherein the composition is administered within 1 hour before sleep.
15. The method according to claim 1 wherein the amount of CBD administered per day is between 0.375 and 3.75 mg per kg of bodyweight of the subject.
16. The method according to claim 1 wherein the amount of CBN administered per day is between 0.09375 and 1.875 mg per kg of bodyweight of the subject.
17. The method according to claim 1 wherein the amount of THC administered per day is between 0.4 and 50 micrograms per kg of bodyweight of the subject.
18. The method according to claim 1 wherein the composition comprises less than 5% of other cannabinoids relative to the combined weight of THC, CBD and CBN in the composition.
19. The method according to claim 18 , wherein the composition comprises no cannabinoids other than THC, CBD and CBN.
20. A composition comprising a tetrahydrocannabinol (THC), a cannabidiol (CBD), and a cannabinol (CBN), wherein the ratio of THC:CBD:CBN by weight is A:B:C where A is between 0.0001 and 1, B is 1, and C is between 0.05 and 1.