Lactic acid bacteria and use thereof
View Patent ↗The present invention relates to Lactobacillus plantarum NK3 and Bifidobacterium longum NK49, which are novel lactic acid bacteria and, more particularly, to a composition comprising novel lactic acid bacteria useful for prevention and treatment of inflammatory diseases.
1. A method of treating an inflammatory disease comprising administering to a mammalian subject having a symptom of the disease an effective amount of Bifidobacterium longum NK49 having the accession number KCCM12088P,
wherein said inflammatory disease is colitis or vaginitis.
2. The method of claim 1 , wherein the method further comprises administering an effective amount of Lactobacillus plantarum NK3 having the accession number KCCM12089P.
3. The method of claim 1 , wherein the Bifidobacterium longum NK49 having the accession number KCCM12088P comprises the 16S rDNA sequence of SEQ ID NO: 2.
4. The method of claim 2 , wherein the Lactobacillus plantarum NK3 having the accession number KCCM12089P comprises the 16S rDNA sequence of SEQ ID NO: 1.
5. The method of claim 1 , wherein the Bifidobacterium longum NK49 having the accession number KCCM12088P is a live bacterial cell thereof or a dead bacterial cell thereof, a culture product thereof, a crushed product thereof or an extract thereof.
6. The method of claim 2 , wherein the Lactobacillus plantarum NK3 having the accession number KCCM12089P is a live bacterial cell thereof or a dead bacterial cell thereof.
7. The method of claim 1 , wherein the said inflammatory disease is colitis and said administering is oral administering.
8. The method of claim 1 , wherein the said inflammatory disease is vaginitis and said administering is oral or intravaginal administering.
9. The method of claim 1 , wherein the effective amount is 1×10 2 to 1×10 11 CFU/kg a day.
10. The method of claim 2 , wherein the effective amount is 1×10 2 to 1×10 11 CFU/kg a day.