Apparatus for perfusion of an excised organ
Disclosed is a device for supporting and connecting an excised organ (such as a heart, a pair of lungs, a kidney, or a liver) during ex vivo perfusion. The device includes a resilient and flexible sheet having a first portion for contacting and supporting the organ thereon, and a second portion comprising an opening for forming a connection between the organ and a conduit to allow fluid communication between the conduit and the organ. The device also includes a magnetic material embedded in the second portion of the sheet for magnetically securing the connection between the conduit and the organ.
1. A device for supporting and connecting an excised organ during perfusion, comprising:
a resilient and flexible sheet having
a first portion for contacting and supporting the organ thereon, and
a second portion comprising an opening for forming a connection between the organ and a conduit to allow fluid communication between the conduit and the organ; and
a magnetic material embedded in the second portion of the sheet for magnetically securing the connection between the conduit and the organ,
wherein the second portion is laterally arranged beside the first portion.
2. The device of claim 1 , wherein the first portion comprises a first material having a first Shore hardness value, and the second portion comprising a second material having a second Shore hardness value, the first Shore hardness value being lower than the second Shore hardness value.
3. The device of claim 2 , wherein the first Shore hardness value is selected from 00-20 to 00-50 to allow the first portion of the sheet to conform to an external shape of the organ when the organ is supported on the sheet.
4. The device of claim 3 , wherein a section in the second portion of the sheet at the opening has a Shore hardness value higher than 0A, selected to limit distention of the section of the sheet under an applied fluid pressure in the opening.
5. The device of claim 1 , wherein the sheet comprises a silicone.
6. The device of claim 1 , wherein different portions of the sheet comprise different silicone materials having different Shore hardness values.
7. The device of claim 1 , wherein the magnetic material comprises particulate magnets or ferromagnetic particulates dispersed around the opening for magnetically attracting a magnetic connector attached to the organ.
8. The device of claim 1 , comprising a magnetic connector embedded in the sheet for coupling with an external magnetic connector.
9. The device of claim 8 , wherein the magnetic connector embedded in the sheet comprises a flange mounted on or connectable to the conduit.
10. The device of claim 1 , wherein the opening of the sheet comprises a first opening for receiving an end of a cannula connected to the organ, a second opening for fluid communication therethrough, and a fluid channel in the sheet connecting the first opening and the second opening.
11. The device of claim 10 , wherein the sheet has a first side and a second side, the first opening is on the first side of the sheet and the channel extends between the first side and the second side within the sheet.
12. The device of claim 11 , wherein the second opening is at an edge of the sheet between the first side and the second side.
13. The device of claim 1 , wherein the sheet comprises a throughhole to allow a fluid tubing to pass therethrough.
14. The device of claim 1 , wherein the sheet comprises a reinforcing frame in the second portion.
15. The device of claim 14 , wherein the reinforcing frame comprises a urethane material.
16. The device of claim 1 , wherein the organ is a heart, and the second portion of the sheet has a plurality of openings comprising a first opening for fluid communication with an aorta of the heart, a second opening for fluid communication with a pulmonary artery of the heart, and a third opening for fluid communication with an atrium of the heart.
17. The device of claim 1 , wherein the connection comprises a cannula, the cannula comprising a pressure sensor or a port for coupling with the pressure sensor.
18. The device of claim 1 , comprising a chamber, wherein the sheet is mounted inside the chamber, the chamber comprising a plurality of ports for connecting a plurality of fluid conduits to the organ supported on the sheet.
19. The device of claim 18 , wherein the chamber comprises a plurality of mounting posts having different heights, and the sheet is mounted on the mounting posts and is inclined such that the first portion is lower than the second portion.
20. A kit comprising the device of claim 1 , and a set of external magnetic connectors each configured for connecting with a respective cannula, wherein the set of magnetic connectors comprises a first connector for connecting with an artery of a heart, and a second connector for connecting with an atrium of the heart, and a third connector for connecting with an aorta of the heart.