Polyketide compound and derivatives thereof for use in the prevention and treatment of a neurological disorder
The present invention relates to a compound, in particular a polyketide compound and derivatives thereof, for use in the prevention and/or treatment of a neurological disorder in an individual. The compound of the invention can promote lactate secretion. A composition comprising the compound of the invention, and a food or food extract enriched with said compound or composition are also provided.
1. A method for treatment of a neurological disorder and/or improvement of memory function in an individual in need thereof, the method comprising administering to the subject a compound of general structural formula (Ia)
wherein R1 to R9 are individually selected from H and CH3; and
R10 to R17 are individually selected from H, C═O, and OH;
or a salt thereof, in an amount effective to promote lactate secretion in the individual,
the neurological disorder is selected from the group consisting of arachnid cysts, attention deficit/hyperactivity disorder (ADHD), autism, bipolar disorder, catalepsy, depression, encephalitis, epilepsy/seizures, infection, locked-in syndrome, meningitis, migraine, multiple sclerosis, myelopathy, Alzheimer's disease, Huntington's disease, Parkinson's disease, Tourette's syndrome, and combinations thereof.
2. The method of claim 1 , wherein the compound is a macrolide.
3. The method of claim 1 , wherein the compound is lactonised between the carboxylic acid group at position 19 and the alcoholic group at position 3, creating an 18 atom ring to form compound A: