IP Library Granted Patent US 11,420,056
Granted Patent B2
US 11,420,056 · App. 16/769,525 · Granted Aug 23, 2022

System for planning and/or providing neuromodulation, especially neurostimulation

Inventors: Marco Capogrosso (Lausanne, CH); Karen Minassian (Vienna, AT); Fabien Wagner (Lausanne, CH); Gregoire Courtine (Lausanne, CH); Miroslav Caban (Eindhoven, NL); Robin Brouns (Eindhoven, NL); Jurriaan Bakker (Eindhoven, NL); Andre Kleibeuker (Eindhoven, NL); Bert Bakker (Eindhoven, NL); Vincent Delattre (Eindhoven, NL)
Assignees: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL); ONWARD MEDICAL N.V.
A61N1/36062A61N1/0551A61N1/36135
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Quick Facts
Patent No.
US 11,420,056
App. No.
16/769,525
Granted
Aug 23, 2022
Kind
B2
Abstract

The present invention relates to methods and systems for planning and/or providing neuromodulation. An example system comprises a neurostimulator comprising a least one electrode, functional mapping module configured and arranged such that based on stimulation related basic data and stimulation related response data and transfer data a digital characteristic functional map is generated and/or provided, which describes the interrelation between the stimulation related basic data and the stimulation related response data and the transfer data, and analysis module configured and arranged such that the digital characteristic functional map may be analyzed in connection with neurostimulation provided by the neurostimulator such that the provided neurostimulation and its response may be analyzed on the basis of the functional map and that on the basis of this analysis a placement analysis of a placement of the electrode is provided.

Claims (32)

1. A system for planning and/or providing spinal cord stimulation comprising:

a neurostimulator comprising at least one electrode;

a functional mapping module configured to:

generate a digital characteristic functional map based on stimulation related basic data, stimulation related response data, and transfer data, wherein, the digital characteristic functional map describes an interrelation between the stimulation related basic data, the stimulation related response data, and the transfer data; and

an analysis module configured to:

analyze the digital characteristic functional map in connection with neurostimulation of a spinal cord by the neurostimulator;

analyze the neurostimulation of the spinal cord and a spinal cord response based on the digital characteristic functional map; and

analyze a placement of the at least one electrode based on the analysis of the neurostimulation and the spinal cord response.

2. The system according to claim 1 , further comprising a stimulation related basic data storage module for storing stimulation related basic data defining parameters of the neurostimulator for treating a patient, the stimulation related basic data storage module comprising at least one set of stimulation related basic data and/or working parameters of the neurostimulator.

3. The system according to claim 1 , further comprising:

a stimulation related response data storage module for storing the stimulation related response data, the stimulation related response data storage module comprising at least one set of stimulation related response data including activation of the spinal cord in response to stimulation provided to the spinal cord.

4. The system according to claim 1 , further comprising:

a data input module configured to receive the stimulation related basic data;

a transfer module configured to:

link and/or translate the stimulation related basic data received by the data input module into the stimulation related response data or artificial response data created by the transfer module, wherein data generated by the transfer module are transfer data, the transfer data comprising link data and/or translation data and/or the artificial response data and/or reference data, and

a transfer response data storage module for storing the transfer data.

5. The system according to claim 1 , further comprising a visualization module.

6. The system according to claim 5 , wherein the visualization module is configured to display at least partially stimulation related basic data and at least partially stimulation related response data.

7. The system according to claim 5 , wherein the visualization module is configured to schematically visualize the stimulation related response data with representations of muscles and/or muscle groups receiving neurostimulation.

8. The system according to claim 1 , further comprising:

a stimulation related response data input module, wherein the system is configured to provide an inverse control by inputting stimulation related response data via the stimulation related response data input module, and

a selection module configured to select suitable stimulation related basic data based on the digital characteristic functional map.

9. The system according to claim 1 , further comprising:

a neuromodulation settings generation module configured to translate the digital characteristic functional map into neuromodulation parameter settings for a neuromodulation treatment of a subject.

10. The system according to claim 9 , further comprising a transfer interface configured to transfer neuromodulation parameter settings to the neurostimulator.

11. The system according to claim 1 , wherein the analysis module is configured to generate a placement proposal based on the functional map and the analysis of the placement.

12. The system according to claim 11 , wherein the placement proposal is displayed by a visualization module.

13. A method for planning and/or providing neuromodulation of a spinal cord, comprising:

linking and/or translating stimulation related basic data into and/or with stimulation related response data and/or artificial response data to generate transfer data, the transfer data comprising link data and/or translation data and/or the artificial response data;

generating a digital characteristic map based on the stimulation related basic data, the stimulation related response data, and the transfer data, the digital characteristic map describing an interrelation between the stimulation related basic data, the stimulation related response data and the transfer data;

generating a placement proposal for placement of at least one electrode providing neurostimulation of the spinal cord based on the digital characteristic map; and

outputting the placement proposal via one or more of a display, a loudspeaker, a beamer, and a projector.

Assignments (4)
SECURITY INTEREST Recorded Aug 14, 2024
From: ONWARD MEDICAL N.V.
To: RUNWAY GROWTH FINANCE CORP., AS COLLATERAL AGENT
Reel/Frame 068287/0393 →
CHANGE OF NAME Recorded Jul 5, 2022
From: ONWARD MEDICAL B.V.
To: ONWARD MEDICAL N.V.
Reel/Frame 060953/0524 →
CHANGE OF NAME Recorded Feb 11, 2021
From: GTX MEDICAL B.V.
To: ONWARD MEDICAL B.V.
Reel/Frame 055281/0775 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 7, 2020
From: CAPOGROSSO, MARCO; MINASSIAN, KAREN; WAGNER, FABIEN; COURTINE, GREGOIRE; CABAN, MIROSLAV; BROUNS, ROBIN; BAKKER, JURRIAAN; KLEIBEUKER, ANDRE; BAKKER, EGBERTUS; DELATTRE, VINCENT
To: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL); GTX MEDICAL B.V.
Reel/Frame 054568/0526 →
Priority Claims (1)
EP 17205363 · Dec 5, 2017 · regional
Continuity (1)
Related Publication 20200391030A1 · Dec 17, 2020