Antiparasitic pour-on compositions
Liquid veterinary pour-on or spot-on composition comprising at least one isoxazoline compound of formula (I) and a pharmaceutically acceptable carrier comprising at least one dermal penetration 5 enhancer comprising menthol and a solvent system comprising a pyrrolidone solvent are disclosed. Methods for using and administering such preparation in the prevention and control of parasite infestations in livestock animals are also disclosed.
1. A liquid cattle pour on composition comprising an effective amount of fluralaner, or a pharmaceutically acceptable salt thereof, wherein the composition is a pour on and comprises
a) from about 1% to about 10% w/v of fluralaner;
b) from about 5% to about 15% w/v of menthol;
c) from about 10% to about 40% w/v of 2-pyrrolidone;
d) from about 10% to about 50% w/v of a propylene glycol dicaprylate/dicaprate;
e) optionally from about 0.01% to about 0.5% (w/v) of a colorant; and
f) isopropyl alcohol, q.s. wherein the concentration of the isopropyl alcohol is from about
20% to about 45% w/v.
2. The liquid cattle pour on composition of claim 1 , comprising:
a) about 5% w/v of fluralaner;
b) about 10% w/v of menthol;
c) from about 33% to about 35% w/v of isopropyl alcohol;
d) about 35% w/v of 2-pyrrolidone; and
e) about 10% w/v of a propylene glycol dicaprylate/dicaprate.
3. The liquid cattle pour on composition of claim 1 , wherein the fluralaner concentration is about 5% w/v.
4. The liquid cattle pour on composition of claim 1 , wherein the menthol concentration is about 10% w/v.
5. The liquid cattle pour on composition of claim 1 , wherein the 2-pyrrolindone concentration is about 20% w/v.
6. The liquid cattle pour on composition of claim 1 , wherein the propylene glycol dicaprylate/dicaprate concentration is about 10% w/v.
7. The liquid cattle pour on composition of claim 1 , wherein the colorant is FD&C Blue no 1, FD&C Yellow no 5, Chlorophyllin or mixtures thereof.
8. A method of protecting a cattle animal from ectoparasite infestation comprising administering an effective dose of the liquid cattle pour on composition of claim 1 .
9. The method of claim 8 , wherein the pour on administration of the liquid cattle pour on composition controls ectoparasite infestation in cattle.
10. The method of claim 8 , wherein the pour on administration of the liquid cattle pour on composition controls tick or lice infestation in cattle.