Patent Application

App. No. 16/773,707

Abstract

Claims (45)

1 . A method of modulating oxygen saturation levels, comprising:

measuring oxygen saturation levels in a patient;

administering inhaled nitric oxide;

adjusting the dose of oxygen in real time to a second dose based on the inhaled nitric oxide;

determining a first oxygen requirement to address an oxygen deficiency;

determining a reduced oxygen requirement based on the generated nitric oxide; and

delivering a dose of supplemental oxygen based on the reduced oxygen requirement and the gas mixture including nitric oxide from the receptacle to the patient.

2 . The method of claim 1 further comprising

mixing a first gas including oxygen and a second gas including a nitric oxide-releasing agent within a receptacle to form a gas mixture, wherein the receptacle includes an inlet, an outlet and a reducing agent; and

contacting the nitric oxide-releasing agent in the gas mixture with the reducing agent to generate nitric oxide

3 . The method of claim 1 wherein adjusting the dose includes titrating the dose of oxygen in real time.

4 . A method of modulating oxygen saturation levels, comprising:

measuring oxygen saturation levels in a patient;

determining a first dose of oxygen to address an oxygen deficiency;

mixing a first gas including oxygen and a second gas including a nitric oxide;

determining a second dose of oxygen based on an amount of nitric oxide to be co-administered with the oxygen, wherein the second dose is lower than the first dose; and

delivering the gas mixture including nitric oxide from the receptacle to the patient.

5 . The method of claim 1 , wherein the method includes an incremental reduction of pO2.

6 .- 12 . (canceled)

13 . The method of claim 1 , wherein the concentration of nitric oxide in the gas mixture delivered is at least 0.01 ppm and at most 2 ppm.

14 . The method of claim 1 , wherein hydrogen is added in the following combinations: (H+O2) or (H+NO) or (H+NO+O2).

15 . (canceled)

16 . The method of claim 1 , further comprising delivering hydrogen, the hydrogen acts to eliminate peroxynitrite, thereby reducing adverse effects of nitric oxide.

17 .- 20 . (canceled)

21 . The method of claim 2 , wherein delivering the gas mixture including nitric oxide from the receptacle to the mammal includes pulsing the gas mixture.

22 . The method of claim 21 , wherein pulsing includes providing the gas mixture for one or more pulses of 1 to 6 seconds.

23 .- 28 . (canceled)

29 . The method of claim 2 , comprising communicating the first gas through a gas conduit to the receptacle and supplying the second gas into the gas conduit immediately prior to the receptacle.

30 .- 34 . (canceled)

35 . The method of claim 1 , wherein the nitric oxide is administered to adults.

36 . The method of claim 1 , wherein the nitric oxide is provided through a cartridge having a length, width, and thickness, an outer surface, and an inner surface, and can be substantially cylindrical in shape.

37 . The method of claim 36 , wherein the thickness between the inner and outer surface is constant, thereby providing a uniform exposure to the reducing agents.

38 . (canceled)

39 . A method of modulating oxygen saturation levels, comprising:

implanting a pulmonary artery pressure sensor;

monitoring pulmonary artery pressure in real time;

measuring oxygen saturation levels in a patient;

administering inhaled nitric oxide;

adjusting the dose of oxygen in real time to a second dose based on the inhaled nitric oxide;

determining a first oxygen requirement to address an oxygen deficiency;

determining a reduced oxygen requirement based on the generated nitric oxide; and

delivering a dose of supplemental oxygen based on the reduced oxygen requirement and the gas mixture including nitric oxide from the receptacle to the patient.

40 . The method of claim 39 , wherein the pulmonary artery pressure sensor is configured to monitor the right heart.

41 . The method of claim 39 , wherein the pulmonary artery pressure sensor is configured to monitor the left heart.

42 . The method of claim 39 , wherein the pulmonary artery pressure sensor is a wireless device.

Assignments (9)