Injectable phenol formulations and methods of their use
Phenol formulations including phenol and an encapsulation agent, such as a cyclodextrin or derivatives thereof, and uses of such formulations.
1. A method for creating a nerve-block in a mammal comprising administering an effective amount of a phenol formulation, the formulation consisting of:
phenol,
a cyclodextrin or derivative thereof complexing at least a portion of the phenol,
at least one pharmacologically acceptable solvent for administration, and
optionally one or more pharmaceutically acceptable excipients.
2. The method according to claim 1 , wherein the administering is by injection.
3. The method according to claim 1 , wherein the administering is by topical application.
4. A method for treating therapeutic, cosmetic, or tissue lysis condition in a patient in need thereof, comprising:
injecting into or applying in proximity of a physiological target area in proximity to or within a nerve, blood vessel, tumour, or tissue growth of the patient an effective amount of a phenol formulation, the formulation consisting of:
phenol,
a cyclodextrin or derivative thereof complexing at least a portion of the phenol,
at least one pharmacologically acceptable solvent for injection, and
optionally one or more pharmaceutically acceptable excipients.
5. The method according to claim 4 , wherein the phenol formulation comprises from about 4% to about 9% by weight phenol, and from about 10% to about 20% by weight cyclodextrin or derivative.
6. The method according to claim 1 , wherein the cyclodextrin is hydroxypropyl-β-cyclodextrin (HP-β-CD).
7. The method according to claim 6 , wherein the concentration of the hydroxypropyl-β-cyclodextrin in the formulation is from about 10% to about 20% by weight (w/w) of the formulation.
8. The method according to claim 7 , wherein the concentration of the hydroxypropyl-β-cyclodextrin is from about 12% to about 18% by weight (w/w) of the formulation.
9. The method according to claim 8 , wherein the concentration of the phenol in the formulation is from about 3% to about 9% by weight (w/w) of the formulation.
10. The method according to claim 9 , wherein the concentration of the phenol is about 6% by weight (w/w) of the formulation.