IP Library Granted Patent US 11,117,869
Granted Patent B2
US 11,117,869 · App. 16/779,188 · Granted Sep 14, 2021

Compounds, compositions and methods for treatment of myopia

Inventors: Eric Carlson (Irvine, CA); Mitchell A. deLong (Chapel Hill, NC); Heeren Gordhan (Durham, NC); Cynthia L. Lichorowic (Raleigh, NC); Jill M. Sturdivant (Chapel Hill, NC)
Assignee: Aerie Pharmaceuticals, Inc.
C07D239/26A61K9/0048C07D213/30C07D213/40C07D405/12C07D409/12C07D471/08
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Quick Facts
Patent No.
US 11,117,869
App. No.
16/779,188
Granted
Sep 14, 2021
Kind
B2
Abstract

Provided herein are 8-methyl-8-azabicyclo[3.2.1]octan-3-yl and pyridin-4-ylmethanyl ester and amide compounds and compositions. Also provided herein are methods of preventing or delaying the onset of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject. Also provided herein are methods of reducing or preventing the progression of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject.

Claims (4)

1. A compound, wherein the compound is:

or a solvate, polymorph or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein the compound is:

or a solvate, polymorph thereof, or a pharmaceutically acceptable salt thereof.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2024
From: AERIE PHARMACEUTICALS, INC.
To: ALCON INC.
Reel/Frame 067822/0168 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 19, 2020
From: GORDHAN, HEEREN; LICHOROWIC, CYNTHIA L.; STURDIVANT, JILL M.
To: AERIE PHARMACEUTICALS, INC.
Reel/Frame 053538/0606 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 31, 2020
From: CARLSON, ERIC; DELONG, MITCHELL A.
To: AERIE PHARMACEUTICALS, INC.
Reel/Frame 051690/0175 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 31, 2020
From: CARLSON, ERIC; DELONG, MITCHELL A.
To: AERIE PHARMACEUTICALS, INC.
Reel/Frame 051690/0214 →