Methods of administering high concentrations of nitric oxide

1. A method of treating pulmonary hypertension, the method comprising administering a dose of nitric oxide (NO) to a patient in need thereof, the dose comprising a delivery concentration of greater than 2,000 ppm NO and being administered at a dosing rate less than or equal to 166 μg NO per second.

2. The method of claim 1 , wherein the delivery concentration is in the range from greater than 2,000 ppm to 20,000 ppm.

3. The method of claim 1 , wherein the delivery concentration is in the range from 2,200 ppm to 5,000 ppm.

4. The method of claim 1 , wherein the dose is in the range from 0.001 to 4.5 mg NO/kg/hr.

5. The method of claim 1 , wherein the dose is administered every breath.

6. The method of claim 1 , wherein the dose is administered intermittently.

7. The method of claim 1 , wherein the nitric oxide is administered in undiluted form such that the delivery concentration is the same as a storage concentration.

8. The method of claim 1 , wherein the dosing rate is less than or equal to 100 μg NO per second.

9. The method of claim 1 , wherein the dosing rate is less than or equal to 83 μg NO per second.

10. The method of claim 1 , wherein the pulmonary hypertension is pulmonary arterial hypertension (PAH).

11. The method of claim 1 , wherein the pulmonary hypertension is associated with chronic obstructive pulmonary disease (COPD).

12. A method of reducing nasal irritation during nitric oxide administration, the method comprising administering a therapeutic gas comprising nitric oxide (NO) to a patient, wherein the therapeutic gas is administered to the patient at a delivery concentration of greater than 2,000 ppm NO and at a dosing rate less than or equal to 166 μg NO per second.

13. The method of claim 12 , wherein the delivery concentration is in the range from greater than 2,000 ppm to 20,000 ppm.

14. The method of claim 12 , wherein the delivery concentration is in the range from 2,200 ppm to 5,000 ppm.

15. The method of claim 12 , wherein the patient is administered therapeutic gas at a dose of 0.001 to 4.5 mg NO/kg/hr.

16. The method of claim 12 , wherein the therapeutic gas is administered every breath.

17. The method of claim 12 , wherein the therapeutic gas is administered intermittently.

18. The method of claim 12 , wherein the dosing rate is less than or equal to 100 μg NO per second.

19. The method of claim 12 , wherein the dosing rate is less than or equal to 83 μg NO per second.

20. The method of claim 12 , wherein the patient is diagnosed with pulmonary arterial hypertension (PAH) or chronic obstructive pulmonary disease (COPD).