Systems and methods for hematocrit impedance measurement using switched capacitor accumulator
There is provided a system for measuring a property of a sample that comprises a test strip for collecting the sample; a diagnostic measuring device configured to receive the test strip and measure a concentration of an analyte in the sample received on the test strip; and the diagnostic measuring device further comprising a processor programmed to execute an analyte correction for correcting a measurement of the sample due to one or more interferents, comprising: calculating an interferent impedance measurement including a magnitude measurement and a phase measurement using a switched capacitor accumulator to measure a phase angle; and adjusting the measurement of the analyte in the sample using that the calculated interferent impedance measurement.
1. A system for measuring a property of a sample, comprising:
a test strip for collecting the sample;
a diagnostic measuring device configured to receive the test strip and measure a concentration of an analyte in the sample received on the test strip; and
the diagnostic measuring device further comprising a processor programmed to execute an analyte correction for correcting a measurement of the sample due to one or more interferents, comprising:
calculating an interferent impedance measurement including a magnitude measurement and a phase measurement using a switched capacitor accumulator to measure a phase angle; and
adjusting the measurement of the analyte in the sample using the calculated interferent impedance measurement
wherein measuring the phase angle comprises measuring time differences using the switch capacitor accumulator within a sample window of multiple setpoints of frequency in the range of 10 kHz to 500 kHz and accumulating the time differences that represent phase over the sample window to generate a signal large enough to be measured to calculate the phase measurement.
2. The system of claim 1 , wherein the analyte is glucose and the at least one interferent is hematocrit.
3. The system of claim 1 , wherein the test strip comprises:
a conductive pattern including at least one electrode at the proximal region of the test strip, electrical strip contacts disposed at a conductive region at the distal region of the test strip, and conductive traces electrically connecting the electrodes to at least some of the electrical strip contacts;
a reagent layer contacting at least a portion of at least one electrode; and
a chamber at the proximal region of the test strip for receiving the sample.
4. The system of claim 1 , wherein the switched capacitor accumulator can measure the phase measurement at high frequencies.
5. A system for measuring a property of a sample, comprising:
a diagnostic measuring device configured to measure a concentration of an analyte in a sample; and
the diagnostic measuring device further comprising a processor programmed to execute an analyte correction for correcting a measurement of the sample due to one or more interferents, comprising:
calculating an interferent impedance measurement including a magnitude measurement and a phase measurement using a switched capacitor accumulator to measure a phase angle; and
adjusting the measurement of the analyte in the sample using the calculated interferent impedance measurement
wherein measuring the phase angle comprises measuring time differences using the switch capacitor accumulator within a sample window of multiple setpoints of frequency in the range of 10 kHz to 500 kHz and accumulating the time differences that represent phase over a sample window to generate a signal large enough to be measured to calculate the phase measurement.
6. The system of claim 5 , wherein the analyte is glucose and the at least one interferent is hematocrit.
7. The system of claim 5 , wherein the switched capacitor accumulator can measure the phase measurement at high frequencies.
8. A method of measuring a property of a sample comprising:
measuring an analyte in a sample;
performing an analyte correction of the measured analyte due to one or more interferents, comprising:
calculating an interferent impedance measurement including a magnitude measurement and a phase measurement using a switched capacitor accumulator to measure a phase angle; and
adjusting the measurement of the analyte in the sample using the calculated interferent impedance measurement
wherein measuring the phase angle comprises measuring time differences using the switch capacitor accumulator within a sample window of multiple setpoints of frequency in the range of 10 kHz to 500 kHz and accumulating the time differences that represent phase over a sample window to generate a signal large enough to be measured to calculate the phase measurement.
9. The method of claim 8 , wherein the analyte is glucose and the at least one interferent is hematocrit.
10. The method of claim 8 , further comprising applying a temperature correction to the interferent impedance measurement.
11. The method of claim 8 , wherein the switched capacitor accumulator can measure the phase measurement at high frequencies.