Infected prosthesis and implant treatment with acoustic pressure shock waves

1. A method comprising determining a type of infection caused by either planktonic bacteria pathogens or biofilm at an infected interface of bone and a prosthesis or an implant fixed to the bone in a human or animal body and applying extracorporeal acoustic pressure shock waves to the infected interface of the bone and the prosthesis or implant in a sufficient amount, based on whether the infection is caused by planktonic bacteria or biofilm, to at least one of disrupt the biofilm and kill the planktonic bacteria pathogens at the infected interface of the bone and the prosthesis or implant.

2. The method of claim 1 further comprising focusing the shock waves into a focal volume that overlaps the infected interface.

3. The method of claim 2 further comprising focusing the shock waves with a shock wave reflector into the focal volume that overlaps the infected interface.

4. The method of claim 3 wherein said focusing is with an ellipsoidal reflector.

5. The method of claim 4 further comprising applying the shock waves with a shock wave source consisting of one of an electrohydraulic generator using spark gap high voltage discharge, an electrohydraulic generator using one or more lasers, a piezoelectric generator using piezo crystals, a piezoelectric generator using piezo ceramics, a piezoelectric generator using piezo fibers, an electromagnetic generator using a flat coil and an acoustic lens, and an electromagnetic generator using a cylindrical coil.

6. The method of claim 3 wherein said focusing is with a parabolic reflector.

7. The method of claim 6 further comprising applying the shock waves with a shock wave source consisting of one of an electrohydraulic generator using spark gap high voltage discharge, an electrohydraulic generator using one or more lasers, a piezoelectric generator using piezo crystals, a piezoelectric generator using piezo ceramics, a piezoelectric generator using piezo fibers, an electromagnetic generator using a flat coil and an acoustic lens, and an electromagnetic generator using a cylindrical coil.

8. The method of claim 3 further comprising applying the shock waves to a hip implant.

9. The method of claim 3 further comprising applying the shock waves with a shock wave source consisting of one of an electrohydraulic generator using spark gap high voltage discharge, an electrohydraulic generator using one or more lasers, a piezoelectric generator using piezo crystals, a piezoelectric generator using piezo ceramics, a piezoelectric generator using piezo fibers, an electromagnetic generator using a flat coil and an acoustic lens, and an electromagnetic generator using a cylindrical coil.

10. The method of claim 3 , wherein the focal volume includes an acoustic pressure wave energy flux density of from 0.1 to 1.0 mJ/mm 2 .

11. The method of claim 2 further comprising applying the shock waves with a shock wave source consisting of one of an electrohydraulic generator using spark gap high voltage discharge, an electrohydraulic generator using one or more lasers, a piezoelectric generator using piezo crystals, a piezoelectric generator using piezo ceramics, a piezoelectric generator using piezo fibers, an electromagnetic generator using a flat coil and an acoustic lens, and an electromagnetic generator using a cylindrical coil.

12. The method of claim 2 , wherein the focal volume includes an acoustic pressure wave energy flux density of from 0.1 to 1.0 mJ/mm 2 .

13. The method of claim 1 further comprising applying the shock waves to a hip implant.

14. The method of claim 13 further comprising applying the shock waves with a shock wave source consisting of one of an electrohydraulic generator using spark gap high voltage discharge, an electrohydraulic generator using one or more lasers, a piezoelectric generator using piezo crystals, a piezoelectric generator using piezo ceramics, a piezoelectric generator using piezo fibers, an electromagnetic generator using a flat coil and an acoustic lens, and an electromagnetic generator using a cylindrical coil.

15. The method of claim 1 further comprising applying the shock waves to an implant selected from the group consisting of a knee implant, ankle implant, orthopedic plate, orthopedic rod and orthopedic screw.

16. The method of claim 15 further comprising applying the shock waves with a shock wave source consisting of one of an electrohydraulic generator using spark gap high voltage discharge, an electrohydraulic generator using one or more lasers, a piezoelectric generator using piezo crystals, a piezoelectric generator using piezo ceramics, a piezoelectric generator using piezo fibers, an electromagnetic generator using a flat coil and an acoustic lens, and an electromagnetic generator using a cylindrical coil.

17. The method of claim 1 further comprising applying the shock waves in combination with delivery of antibiotics to the human or animal body.

18. The method of claim 1 further comprising applying the shock waves with a shock wave source consisting of one of an electrohydraulic generator using spark gap high voltage discharge, an electrohydraulic generator using one or more lasers, a piezoelectric generator using piezo crystals, a piezoelectric generator using piezo ceramics, a piezoelectric generator using piezo fibers, an electromagnetic generator using a flat coil and an acoustic lens, and an electromagnetic generator using a cylindrical coil.