IP Library › Granted Patent US 11,083,703
Granted Patent B2
US 11,083,703 · App. 16/790,849 · Granted Aug 10, 2021

Prodrugs of fumarates and their use in treating various diseases

Inventors: Tarek A. Zeidan (Lexington, MA); Scott Duncan (Bedford, MA); Christopher P. Hencken (Boston, MA); Thomas Andrew Wynn (Lexington, MA); Carlos N. Sanrame (Lexington, MA)
Assignee: Alkermes Pharma Ireland Limited
A61K31/225C07C219/08C07C229/16C07C233/18C07C233/91C07C235/88C07C317/18C07C317/28C07D207/06C07D207/40C07D209/52C07D211/06C07D211/38C07D295/088C07D491/113
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Quick Facts
Patent No.
US 11,083,703
App. No.
16/790,849
Granted
Aug 10, 2021
Kind
B2
Abstract

The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.

Claims (5)

1. A compound having the formula

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof.

3. A method of treating multiple sclerosis in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the compound of claim 1 .

4. A method of treating multiple sclerosis in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition of claim 2 .

Assignments (5)
SECURITY INTEREST Recorded Feb 13, 2026
From: ALKERMES PHARMA IRELAND LIMITED
To: JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT
Reel/Frame 074858/0405 →
RELEASE OF SECURITY INTEREST IN PATENTS PREVIOUSLY RECORDED AT REEL/FRAME (073213/0302) Recorded Feb 13, 2026
From: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
To: ALKERMES PHARMA IRELAND LIMITED
Reel/Frame 074858/0429 →
SECURITY INTEREST Recorded Oct 23, 2025
From: ALKERMES PHARMA IRELAND LIMITED
To: JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT
Reel/Frame 073213/0302 →
RELEASE OF PATENT SECURITY AGREEMENTS Recorded Dec 24, 2024
From: MORGAN STANLEY SENIOR FUNDING, INC.
To: ALKERMES PHARMA IRELAND LIMITED
Reel/Frame 069771/0701 →
SECURITY AGREEMENT Recorded Jul 17, 2023
From: ALKERMES PHARMA IRELAND LIMITED
To: MORGAN STANLEY SENIOR FUNDING, INC.
Reel/Frame 064286/0821 →