TRPV4 antagonists

1. A method of treating a disease selected from: ocular edema, glaucoma, and retinopathy, in a human subject which method comprises administering to a human subject in need thereof a therapeutically effective amount of a compound according to Formula (I)

wherein:

R 1 is selected from:

aryl,

aryl substituted from 1 to 4 times by R a ,

heteroaryl,

heteroaryl substituted from 1 to 4 times by R a ,

bicycloheteroaryl, and

bicycloheteroaryl substituted from 1 to 4 times by R a ;

R 2 is selected from:

aryl,

aryl substituted from 1 to 4 times by R b ,

heteroaryl,

heteroaryl substituted from 1 to 4 times by R b ,

bicycloheteroaryl, and

bicycloheteroaryl substituted from 1 to 4 times by R b , and

Y 1 is selected from:

C 1-6 alkyl, and

C 1-6 alkyl substituted with from: 1 to 9 substituents independently selected from:

fluoro,

chloro,

bromo,

iodo,

—OC 1-6 alkyl,

—OC 1-6 alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —NH 2 , and CN,

mercapto,

—S(O)H,

—S(O) 2 H,

oxo,

hydroxy,

amino,

—NHR x11 ,

wherein R x11 is selected from C 1-6 alkyl, and C 1-6 alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —NH 2 , CN, —OC 1-5 alkyl,

—OC 1-5 alkyl substituted from 1 to 6 times by fluoro and —NH 2 , —NR x12 R x13 ,

wherein R x12 and R x13 are each independently selected from C 1-6 alkyl, and C 1-6 alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —NH 2 , and —CN,

—C(O)NH 2 ,

aryl,

—Oaryl,

heteroaryl,

—Oheteroaryl,

—S(O) 2 NH 2 ,

—NHS(O) 2 H,

nitro, and

cyano, or

Y 1 is taken together with the adjacent —OH to form a heterocyclic ring selected from:

morpholinyl,

morpholinyl substituted by —CH 3 , and

oxazolidin-2-one;

each R a is independently selected from:

fluoro,

chloro,

bromo,

iodo,

—OH,

C 1-6 alkyl,

C 1-6 alkyl substituted with from 1 to 5 substituents independently selected from: fluoro, chloro, bromo, iodo, C 1-4 alkoxy, —OH, C 1-4 alkyl, phenyl, oxo,—NO2, —NH 2 and —CN,

cyano,

—OC 1-6 alkyl,

—OC 1-6 alkyl substituted with from 1 to 5 substituents independently selected from: fluoro, chloro, bromo, iodo, C 1-4 alkoxy, —OH, C 1-4 alkyl, phenyl, oxo, —NO2, —NH 2 and —CN,

—Ophenyl,

—C(O)OC 1-6 alkyl,

—C(O)OC 1-6 alkyl substituted 1 to 5 times by fluoro, and

—Ocycloalkyl; and

each R b is independently selected from:

fluoro,

chloro,

bromo,

iodo,

—OH,

C 1-6 alkyl,

C 1-6 alkyl substituted with from 1 to 5 substituents independently selected from: fluoro, chloro, bromo, iodo, C 1-4 alkoxy, —OH, C 1-4 alkyl, phenyl, oxo, —NO2, —NH 2 and —CN,

cyano,

—OC 1-6 alkyl,

—OC 1-6 alkyl substituted with from 1 to 5 substituents independently selected from: fluoro, chloro, bromo, iodo, C 1-4 alkoxy, —OH, C 1-4 alkyl, phenyl, oxo, —NO2, —NH 2 and —CN,

phenyl,

C 1-4 alkylphenyl,

—C≡C—Si(CH3) 3 , and

—C≡C-cycloalkyl;

or a pharmaceutically acceptable salt thereof.

2. The method according to claim 1 , wherein the compound is represented by the following Formula (II):

wherein:

R 21 is selected from:

aryl,

aryl substituted from 1 to 3 times by R a2 ,

heteroaryl,

heteroaryl substituted from 1 to 3 times by R a2 ,

bicycloheteroaryl, and

bicycloheteroaryl substituted from 1 to 3 times by R a2 ;

R 22 is selected from:

aryl,

aryl substituted from 1 to 3 times by R b2 ,

bicycloheteroaryl,

bicycloheteroaryl substituted from 1 to 3 times by R b2 ;

heteroaryl, and

heteroaryl substituted from 1 to 3 times by R b2 , and

Y 21 is selected from:

C 1-6 alkyl, and

C 1-6 alkyl substituted with from: 1 to 9 substituents independently selected from:

fluoro,

chloro,

bromo,

iodo,

—OC 1-6 alkyl,

—OC 1-6 alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —NH 2 , and —CN,

mercapto,

—S(O)H,

—S(O) 2 H,

oxo,

hydroxy,

amino,

—NHR x21 ,

wherein R x21 is selected from C 1-6 alkyl, and C 1-6 alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —NH 2 , and —CN,

—NR x22 R x23 ,

wherein R x22 and R x23 are each independently selected from C 1-6 alkyl, and C 1-6 alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —NH 2 , and —CN,

—C(O)NH 2 ,

aryl,

—Oaryl,

heteroaryl,

—Oheteroaryl,

—S(O) 2 NH 2 ,

—NHS(O) 2 H,

nitro, and

cyano, or

Y 21 is taken together with the adjacent —OH to form a heterocyclic ring selected from:

morpholinyl,

morpholinyl substituted by —CH 3 , and

oxazolidin-2-one;

each R ae is independently selected from:

fluoro,

chloro,

bromo,

iodo,

—OH,

C 1-6 alkyl,

C 1-6 alkyl substituted with from 1 to 5 substituents independently selected from: fluoro, chloro, bromo, iodo, C 1-4 alkoxy, —OH, C 1-4 alkyl, phenyl, oxo, —NO2, —NH 2 and —CN,

cyano,

—OC 1-6 alkyl,

—OC 1-6 alkyl substituted with from 1 to 5 substituents independently selected from: fluoro, chloro, bromo, iodo, C 1-4 alkoxy, —OH, C 1-4 alkyl, phenyl, oxo, —NO2, —NH 2 and —CN,

—Ophenyl,

—C(O)OC 1-5 alkyl,

—C(O)OC 1-5 alkyl substituted 1 to 5 times by fluoro, and

—Ocycloalkyl; and

each R b2 is independently selected from:

fluoro,

chloro,

bromo,

iodo,

—OH,

C 1-6 alkyl,

C 1-6 alkyl substituted with from 1 to 5 substituents independently selected from: fluoro, chloro, bromo, iodo, C 1-4 alkoxy, —OH, C 1-4 alkyl, phenyl, oxo, —NO2, —NH 2 and —CN,

cyano,

—OC 1-6 alkyl,

—OC 1-6 alkyl substituted with from 1 to 5 substituents independently selected from: fluoro, chloro, bromo, iodo, C 1-4 alkoxy, —OH, C 1-4 alkyl, phenyl, oxo, —NO2, —NH 2 and —CN,

phenyl,

C 1-4 alkylphenyl,

—C≡C—Si(CH3) 3 , and

—C≡C-cycloalkyl;

or a pharmaceutically acceptable salt thereof.

3. The method of claim 1 , wherein the compound is represented by the following Formula (III):

wherein:

R 31 is selected from:

phenyl,

phenyl substituted from 1 to 3 times by R a3 ,

benzo[c][1,2,5]oxadiazolyl,

benzo[c][1,2,5]oxadiazolyl substituted from 1 to 3 times by R a3 ,

pyrimidinyl,

pyrimidinyl substituted from 1 to 3 times by R a3 ,

naphthalenyl,

naphthalenyl substituted from 1 to 3 times by R a3 ,

pyridinyl, and

pyridinyl substituted from 1 to 3 times by R a3 ;

R 32 is selected from:

phenyl,

phenyl substituted from 1 to 3 times by R b3 ,

pyridinyl,

pyridinyl substituted from 1 to 3 times by R b3 ,

benzo[c][1,2,5]oxadiazolyl,

benzo[c][1,2,5]oxadiazolyl substituted from 1 to 3 times by R b3 ,

thiophenyl,

thiophenyl substituted from 1 to 3 times by R b3 ,

thiazolyl,

thiazolyl substituted from 1 to 3 times by R b3 ,

pyrazolyl,

pyrazolyl substituted from 1 to 3 times by R b3 ,

imidazo [2,1-b]thiazolyl,

imidazo[2,1-b]thiazolyl substituted from 1 to 3 times by R b3 ,

pyrimidinyl,

pyrimidinyl substituted from 1 to 3 times by R b3 ,

pyridazinyl, and

pyridazinyl substituted from 1 to 3 times by R b3 ; and

Y 31 is selected from:

—CH 2 OH,

—CH(OH)CH 3 ,

—CH(OH)CH 2 CH 3 ,

—CH(OH)CH 2 CH 2 CH 3 ,

—CH(OH)CH 2 CH(CH 3 ) 2 ,

—C(OH)(CH 3 ) 2 ,

—CH 2 NH 2 ,

—CH 2 NHR x30 ,

—CH 2 NR x30 R x30 , and

—CH(NH 2 )CH 3 , or

Y 31 is taken together with the adjacent —OH to form a heterocyclic ring selected from:

morpholinyl,

morpholinyl substituted by —CH 3 , and

oxazolidin-2-one,

wherein each R x30 is independently selected from: C 1-6 alkyl, and C 1-6 alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —NH 2 , and —CN;

each R a3 is independently selected from:

fluoro,

chloro,

bromo,

iodo,

—OH,

C 1-6 alkyl,

cyano,

—CF 3 ,

—C 1-5 alkylCF 3 ,

—CHF 2 ,

—CH 2 F,

—OC 1-5 alkyl,

—OCF 3 ,

—OC 1-5 alkylCF 3 ,

—Ophenyl,

—Obenzyl,

—C 1-5 alkylCN,

—C(O)OC 1-5 alkyl,

—C(O)OH, and

—Ocycloalkyl; and

each R b3 is independently selected from:

fluoro,

chloro,

bromo,

iodo,

—OH,

C 1-6 alkyl,

cyano,

—CF 3 ,

—C 1-5 alkylCF 3 ,

—CHF 2 ,

—CH 2 F,

—OC 1-5 alkyl,

—OCF 3 ,

—OC 1-5 alkylCF 3 ,

—C(O)CH 3 ,

—OCHF 2 ,

phenyl,

—C≡C—Si(CH 3 ) 3 ,

—C≡C-cycloalkyl, and

—C≡C-phenyl;

or a pharmaceutically acceptable salt thereof.

4. The method of claim 1 , wherein the compound is represented by the following Formula (IV):

wherein:

R 41 is selected from:

phenyl, and

phenyl substituted from 1 to 3 times by R a4 ;

R 42 is selected from:

phenyl,

phenyl substituted from 1 to 3 times by R b4 ,

pyridinyl, and

pyridinyl substituted from 1 to 3 times by R b4 ; and

Y 41 is selected from:

—CH 2 OH,

—CH 2 NH 2 ,

—CH 2 NHR x40 ,

—CH 2 NR x40 R x40 , and

—CH(NH 2 )CH 3 , or

Y 41 is taken together with the adjacent —OH to form a heterocyclic ring selected from:

morpholinyl,

morpholinyl substituted by —CH 3 , and

oxazolidin-2-one,

wherein each R x40 is independently selected from: C 1-6 alkyl, and C 1-6 alkyl substituted with from 1 to 6 substituents independently selected from: fluoro, oxo, —OH, —NH 2 , and —CN;

each R a4 is independently selected from:

fluoro,

chloro,

bromo,

iodo,

—OH,

C 1-6 alkyl,

cyano,

—CF 3 ,

—C 1-5 alkylCF 3 ,

—CHF 2 ,

—CH 2 F,

—OC 1-5 alkyl,

—OCF 3 ,

—OC 1-5 alkylCF 3 ,

—Ophenyl,

—Obenzyl,

—C 1-5 alkylCN,

—C(O)OC 1-5 alkyl,

—C(O)OH, and

—Ocycloalkyl; and

each R b4 is independently selected from:

fluoro,

chloro,

bromo,

iodo,

—OH,

C 1-6 alkyl,

cyano, —CF 3 , —C 1-5 alkylCF 3 ,

—CHF 2 ,

—CH 2 F,

—OC 1-5 alkyl,

—OCF 3 ,

—OC 1-5 alkylCF 3 ,

—C(O)CH 3 ,

—OCHF 2 ,

phenyl,

—C≡C—Si(CH 3 ) 3 ,

—C≡C-cycloalkyl, and

—C≡C-phenyl;

or a pharmaceutically acceptable salt thereof.

5. The method of claim 1 wherein the compound is selected from:

4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2,4-dichlorophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((4-chloro-2-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

(3R,4S)-1-((2,4-dichlorophenyl)sulfonyl)-4-(3,4-difluorophenoxy)-3-(hydroxymethyl)pyrrolidin-3-ol;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((6-(trifluoromethyl)pyridin-3-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

2-(((3R,4S)-4-(4-chlorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl) sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(benzo[c][1,2,5]oxadiazol-5-yloxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

5-chloro-2-(((3R,4S)-4-(3,4-difluorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)benzonitrile;

2-(((3R,4S)-4-(4-cyano-2-fluorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl) sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(4-cyano-2-methoxyphenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl) sulfonyl)-5-(trifluoromethyl)benzonitrile;

4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(4-cyano-2-ethoxyphenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl) sulfonyl)-5-(trifluoromethyl)benzonitrile;

5-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)pyrimidine-2-carbonitrile;

2-(((3R,4S)-4-(2-chloro-4-cyanophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl) sulfonyl)-5-(trifluoromethyl)benzonitrile;

4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2,3-difluorobenzonitrile;

2-(((3R,4S)-4-(4-cyano-2-methylphenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(4-cyano-2-(trifluoromethyl)phenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

6-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-naphthonitrile;

4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2,5-difluorobenzonitrile;

4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2,6-difluorobenzonitrile;

4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-(trifluoromethoxy)benzonitrile;

5-chloro-2-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-(3,4,5-trifluorophenoxy)pyrrolidin-1-yl)sulfonyl)benzonitrile;

5-chloro-2-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-(2,3,4-trifluorophenoxy)pyrrolidin-1-yl)sulfonyl)benzonitrile;

5-chloro-2-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-(2,4,5-trifluorophenoxy)pyrrolidin-1-yl)sulfonyl)benzonitrile;

2-(((3R,4S)-4-(3,4-difluorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-(3,4,5-trifluorophenoxy)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-(2,4,5-trifluorophenoxy)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-(2,3,4-trifluorophenoxy)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(4-cyanophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(4-chloro-3-fluorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(3-fluoro-4-(trifluoromethyl)phenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(4-(cyanomethyl)phenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(3-(cyanomethyl)phenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

methyl 5-cyano-2-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)benzoate;

(3R,4S)-1-((2,4-dichlorophenyl)sulfonyl)-3-(hydroxymethyl)-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)pyrrolidin-3-ol;

5-(((3S,4R)-1-((2,4-dichlorophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-3-fluoropicolinonitrile;

2-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-(4-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(4-fluoro-3-(trifluoromethyl)phenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(3,4-dichlorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(3-fluoro-4-(trifluoromethoxy)phenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(3-chloro-4-fluorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(3-fluoro-4-methoxyphenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(4-cyano-2-isopropoxyphenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(4-cyano-2-cyclopropoxyphenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-phenoxypyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(4-fluorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(4-chloro-2-methoxyphenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

4-(((3S,4R)-1-((2-chloro-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)benzonitrile;

2-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-(4-(trifluoromethoxy)phenoxy)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-(p-tolyloxy)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-(4-methoxyphenoxy)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(3-cyanophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(5-cyano-2-methoxyphenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-((2-(trifluoromethyl)pyrimidin-5-yl)oxy)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-(4-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)sulfonyl)benzonitrile;

4-(((3S,4R)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-1-naphthonitrile;

4-(((3S,4R)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((7-chlorobenzo[c][1,2,5]oxadiazol-4-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-(benzo[c][1,2,5]oxadiazol-5-ylsulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

3-(((3R,4S)-4-(4-cyano-3-fluorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)picolinonitrile;

4-(((3S,4R)-1-((2-chloro-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-bromo-4-methoxyphenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-bromo-4-(trifluoromethoxy)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-chloro-4-(trifluoromethoxy)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((4-bromo-2-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((4-cyano-2-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

5-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)picolinonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((4-(trifluoromethyl)phenyl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

4-(((3S,4R)-1-((4-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((4-acetyl-2-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

5-(((3S,4R)-1-((2,4-dichlorophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)picolinonitrile;

5-(((3S,4R)-1-((2-chloro-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)picolinonitrile;

5-(((3S,4R)-1-((2-chloro-4-methylphenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)picolinonitrile;

5-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((2,4,6-trichlorophenyl)sulfonyl)pyrrolidin-3-yl)oxy)picolinonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((2,4,6-trichlorophenyl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

4-(((3S,4R)-1-((2-chloro-4-methylphenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

5-(((3R,4S)-4-(4-cyano-3-fluorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)picolinonitrile;

4-(((3S,4R)-1-((4-cyano-2-methylphenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((2-methyl-4-(trifluoromethyl)phenyl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

5-(((3R,4S)-4-(4-cyano-2,5-difluorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)picolinonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((5-(trifluoromethyl)pyridin-2-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

4-(((3S,4R)-1-((2-chlorophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((5-chlorothiophen-2-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((2-methyl-4-(trifluoromethyl)thiazol-5-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

4-(((3S,4R)-1-((2,4-dichlorothiazol-5-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((4-chloro-1-methyl-1H-pyrazol-5-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((6-chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((6-chloropyridin-3-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2,6-dichloropyridin-3-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-ethynylphenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2,3-dichlorophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((3-chloro-2-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2,6-dichloro-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-chloro-4-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((4-(difluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((6-bromopyridin-3-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-chloro-6-(trifluoromethyl)pyridin-3-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((4-chlorophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((4-bromophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((4-iodophenyl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

4-(((3S,4R)-1-((4-cyano-2-methoxyphenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((5-bromopyridin-2-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

3-chloro-4-(((3R,4S)-4-(4-chlorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)benzonitrile;

2-(((3R,4S)-4-(4-chlorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)benzonitrile;

3-bromo-4-(((3R,4S)-4-(4-chlorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)benzonitrile;

5-(((3R,4S)-4-(4-chlorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)picolinonitrile;

3-(((3R,4S)-4-(4-chlorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)picolinonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((4-(2,2,2-trifluoroethyl)phenyl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((5-(trifluoromethyl)thiophen-2-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

4-(((3S,4R)-1-((4-cyano-2-fluorophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-cyano-4-iodophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-chloro-4-iodophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

2-fluoro-4-(((3S,4R)-1-((3-fluoro-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)benzonitrile;

4-(((3S,4R)-1-((2-bromophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

2-fluoro-4-(((3S,4R)-1-((3-fluoro-4-methylphenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)benzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((2-iodophenyl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

4-(((3S,4R)-1-((2-bromo-4-chlorophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((4-bromo-2-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-(difluoromethoxy)pyridin-3-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((4-bromo-1-methyl-1H-pyrazol-5-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((4-chloro-1,3-dimethyl-1H-pyrazol-5-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

(3R,4S)-4-(benzo[c][1,2,5]oxadiazol-5-yloxy)-1-((2-fluoro-4-(trifluoromethyl)phenyl)sulfonyl)-3-(hydroxymethyl)pyrrolidin-3-ol;

4-(((3S,4R)-1-((6-(difluoromethoxy)pyridin-3-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((5-(trifluoromethoxy)pyridin-2-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((2-(trifluoromethyl)pyrimidin-5-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

4-(((3S,4R)-1-((4-chloro-3-(trifluoromethoxy)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((5-iodopyridin-2-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

5-(((3R,4S)-4-(4-cyano-3-fluorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-6-methylpicolinonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((6-(trifluoromethoxy)pyridin-2-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((6-(2,2,2-trifluoroethoxy)pyridazin-3-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

4-(((3S,4R)-1-((6-(difluoromethoxy)pyridin-2-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-1-((2-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-1-((2-cyano-4-fluorophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-1-((4-chloro-2-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

3-(((3S,4S)-4-(4-cyano-3-fluorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)picolinonitrile;

4-(((3S,4S)-1-((2-chloro-4-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-1-((2,4-dichlorophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-1-((4-bromo-2-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-1-((2-bromo-4-fluorophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-1-((2-cyano-4-methoxyphenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

2-(((3S,4S)-4-(4-chlorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3S,4S)-4-(4-chlorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-fluorobenzonitrile;

2-(((3S,4S)-3-hydroxy-3-(hydroxymethyl)-4-(4-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

5-fluoro-2-(((3S,4S)-3-hydroxy-3-(hydroxymethyl)-4-(4-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)sulfonyl)benzonitrile;

3-chloro-4-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-(4-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)sulfonyl)benzonitrile;

5-chloro-2-(((3S,4S)-4-(4-chlorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)benzonitrile;

5-chloro-2-(((3S,4S)-3-hydroxy-3-(hydroxymethyl)-4-(4-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)sulfonyl)benzonitrile;

5-fluoro-2-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-(4-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)sulfonyl)benzonitrile;

5-chloro-2-(((3R,4S)-4-(4-chlorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)benzonitrile;

2-(((3R,4S)-4-(4-chlorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-fluorobenzonitrile;

5-chloro-2-(((3R,4S)-3-hydroxy-3-(hydroxymethyl)-4-(4-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)sulfonyl)benzonitrile;

4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluoro-5-(2,2,2-trifluoroethoxy)benzonitrile;

4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluoro-5-methoxybenzonitrile;

4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-5-ethoxy-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluoro-5-propoxybenzonitrile;

4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluoro-5-isopropoxybenzonitrile;

4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluoro-5-hydroxybenzonitrile;

5-(benzyloxy)-4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

5-butoxy-4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluoro-5-isobutoxybenzonitrile;

2-(((3R,4S)-4-(4-cyano-2-propoxyphenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(4-cyano-2-(2,2,2-trifluoroethoxy)phenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(4-cyano-2-hydroxyphenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(2-butoxy-4-cyanophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(4-cyano-2-isobutoxyphenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

2-(((3R,4S)-4-(2-(benzyloxy)-4-cyanophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-5-(trifluoromethyl)benzonitrile;

4-(((3S,4R)-1-((4-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-3-(2,2,2-trifluoroethoxy)benzonitrile;

4-(((3S,4R)-1-((2-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluoro-5-(2,2,2-trifluoroethoxy)benzonitrile;

5-(((3R,4S)-4-(4-cyano-5-fluoro-2-(2,2,2-trifluoroethoxy)phenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)picolinonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((6-(trifluoromethyl)pyridin-3-yl)sulfonyl)pyrrolidin-3-yl)oxy)-5-(2,2,2-trifluoroethoxy)benzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-(phenylsulfonyl)pyrrolidin-3-yl)oxy)-5-(2,2,2-trifluoroethoxy)benzonitrile;

4-(((3S,4R)-1-((2,4-dichlorophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluoro-5-(2,2,2-trifluoroethoxy)benzonitrile;

4-(((3S,4R)-1-((4-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluoro-5-(2,2,2-trifluoroethoxy)benzonitrile;

4-(((3S,4R)-1-((2-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluoro-5-isobutoxybenzonitrile;

4-(((3S,4R)-1-((4-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluoro-5-isobutoxybenzonitrile;

5-(((3R,4S)-4-(4-cyano-5-fluoro-2-isobutoxyphenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)picolinonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((4-(trifluoromethyl)phenyl)sulfonyl)pyrrolidin-3-yl)oxy)-5-isobutoxybenzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((6-(trifluoromethyl)pyridin-3-yl)sulfonyl)pyrrolidin-3-yl)oxy)-5-isobutoxybenzonitrile;

5-(((3R,4S)-4-(4-cyano-2-(2,2,2-trifluoroethoxy)phenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)picolinonitrile;

4-(((3S,4R)-1-((2-cyanophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-3-(2,2,2-trifluoroethoxy)benzonitrile;

4-(((3S,4R)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-3-(2,2,2-trifluoroethoxy)benzonitrile;

4-(((3S,4R)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluoro-5-(2,2,2-trifluoroethoxy)benzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((6-methylpyridazin-3-yl)sulfonyl)pyrrolidin-3-yl)oxy)-5-isobutoxybenzonitrile;

4-(((3S,4R)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxy-4-((S)-1-hydroxybutyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-((R)-1-hydroxyethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxy-4-(1-hydroxyethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxy-4-((S)-1-hydroxy-3-methylbutyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(1-hydroxyethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-((S)-1-hydroxyethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxy-4-((R)-1-methoxyethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxy-4-((R)-1-hydroxypropyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxy-4-((R)-1-hydroxy-3-methylbutyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxy-4-((R)-1-hydroxybutyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-cyano-4-methoxyphenyl)sulfonyl)-4-hydroxy-4-((S)-1-hydroxyethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-cyanophenyl)sulfonyl)-4-hydroxy-4-((S)-1-hydroxyethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-cyano-4-fluorophenyl)sulfonyl)-4-hydroxy-4-((S)-1-hydroxyethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((4-chloro-2-cyanophenyl)sulfonyl)-4-hydroxy-4-((S)-1-hydroxyethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

3-(((3R,4S)-4-(4-cyano-3-fluorophenoxy)-3-hydroxy-3-((S)-1-hydroxyethyl)pyrrolidin-1-yl)sulfonyl)picolinonitrile;

4-(((3S,4R)-1-((2,4-dichlorophenyl)sulfonyl)-4-hydroxy-4-((S)-1-hydroxyethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-chloro-4-cyanophenyl)sulfonyl)-4-hydroxy-4-((S)-1-hydroxyethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-((R)-1-hydroxyethyl)-1-((6-(trifluoromethyl)pyridin-3-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

2-fluoro-4-(((3S,4R)-1-((5-fluoropyridin-2-yl)sulfonyl)-4-hydroxy-4-((R)-1-hydroxyethyl)pyrrolidin-3-yl)oxy)benzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-((R)-1-hydroxyethyl)-1-((6-(trifluoromethoxy)pyridin-3-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-((R)-1-hydroxyethyl)-1-((4-iodophenyl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-((R)-1-hydroxyethyl)-1-((5-(trifluoromethoxy)pyridin-2-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

4-(((3S,4R)-1-((5-(difluoromethyl)pyridin-2-yl)sulfonyl)-4-hydroxy-4-((R)-1-hydroxyethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((6-(difluoromethyl)pyridin-3-yl)sulfonyl)-4-hydroxy-4-((R)-1-hydroxyethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((6-(difluoromethoxy)pyridin-3-yl)sulfonyl)-4-hydroxy-4-((R)-1-hydroxyethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxy-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluoro-5-(2,2,2-trifluoroethoxy)benzonitrile;

4-(((3S,4R)-1-((2-cyano-4-methylphenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-cyano-4-ethylphenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3R,4S)-4-(4-cyano-3-fluorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl) sulfonyl)-[1,1′-biphenyl]-3-carbonitrile;

4-(((3S,4R)-1-((2-cyano-4-(prop-1-yn-1-yl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-cyano-4-ethynylphenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-cyano-4-((trimethylsilyl)ethynyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((4-(prop-1-yn-1-yl)phenyl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((6-(prop-1-yn-1-yl)pyridin-3-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

4-(((3S,4R)-1-((4-cyano-2-(prop-1-yn-1-yl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((2-ethynyl-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((6-(cyclopropylethynyl)pyridin-3-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((5-(prop-1-yn-1-yl)pyridin-2-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

4-(((3S,4R)-1-((5-ethynylpyridin-2-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((5-(3,3-dimethylbut-1-yn-1-yl)pyridin-2-yl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

2-fluoro-4-(((3S,4R)-4-hydroxy-4-(hydroxymethyl)-1-((5-(phenylethynyl)pyridin-2-yl)sulfonyl)pyrrolidin-3-yl)oxy)benzonitrile;

6-(((3R,4S)-4-(4-cyano-3-fluorophenoxy)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)nicotinonitrile;

4-(((3S,4R)-1-((2-cyano-4-(trifluoromethoxy)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-4-(aminomethyl)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxypyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-4-(aminomethyl)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxypyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-4-(aminomethyl)-1-((4-chloro-2-cyanophenyl)sulfonyl)-4-hydroxypyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-1-((4-chloro-2-cyanophenyl)sulfonyl)-4-hydroxy-4-(((2-hydroxyethyl)amino)methyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-((methylamino)methyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-((ethylamino)methyl)-4-hydroxypyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-((isopropylamino)methyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-4-(aminomethyl)-1-((4-chloro-2-cyanophenyl)sulfonyl)-4-hydroxypyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-4-(aminomethyl)-1-((4-chloro-1-methyl-1H-pyrazol-5-yl)sulfonyl)-4-hydroxypyrrolidin-3-yl)oxy)-2-fluorobenzonitrile, 2,2,2-trifluoroacetate;

4-(((3S,4S)-4-(aminomethyl)-1-((5-fluoropyridin-2-yl)sulfonyl)-4-hydroxypyrrolidin-3-yl)oxy)-2-fluorobenzonitrile, 2,2,2-trifluoroacetate;

5-(((3S,4S)-3-(aminomethyl)-4-(4-cyano-3-fluorophenoxy)-3-hydroxypyrrolidin-1-yl)sulfonyl)picolinonitrile, 2,2,2-trifluoroacetate;

4-(((3S,4S)-4-(aminomethyl)-1-((5-(difluoromethyl)pyridin-2-yl)sulfonyl)-4-hydroxypyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-4-(aminomethyl)-4-hydroxy-1-((6-(trifluoromethyl)pyridin-3-yl)sulfonyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-4-(aminomethyl)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxypyrrolidin-3-yl)oxy)benzonitrile;

4-(((3S,4S)-4-(aminomethyl)-1-((5-(difluoromethoxy)pyridin-2-yl)sulfonyl)-4-hydroxypyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-4-(aminomethyl)-4-hydroxy-1-((5-(trifluoromethoxy)pyridin-2-yl)sulfonyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-4-(aminomethyl)-4-hydroxy-1-((6-(trifluoromethoxy)pyridin-3-yl)sulfonyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-4-(aminomethyl)-4-hydroxy-1-((5-iodopyridin-2-yl)sulfonyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4S)-4-(aminomethyl)-1-((5-bromopyridin-2-yl)sulfonyl)-4-hydroxypyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((4S,5R)-2-((4-chloro-2-cyanophenyl)sulfonyl)-9-methyl-6-oxa-2,9-diazaspiro[4.5]decan-4-yl)oxy)-2-fluorobenzonitrile;

4-(((4S,5S)-2-((4-chloro-2-cyanophenyl)sulfonyl)-6-oxa-2,9-diazaspiro[4.5]decan-4-yl)oxy)-2-fluorobenzonitrile;

4-(((5S,9S)-7-((4-chloro-2-cyanophenyl)sulfonyl)-2-oxo-1-oxa-3,7-diazaspiro[4.4]nonan-9-yl)oxy)-2-fluorobenzonitrile;

4-(((5R,9S)-7-((4-chloro-2-cyanophenyl)sulfonyl)-2-oxo-1-oxa-3,7-diazaspiro [4.4]nonan-9-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-4-((R)-1-aminoethyl)-1-((5-chloropyridin-2-yl) sulfonyl)-4-hydroxypyrrolidin-3-yl)oxy)-2-fluorobenzonitrile;

4-(((3S,4R)-4-((S)-1-aminoethyl)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxypyrrolidin-3-yl)oxy)-2-fluorobenzonitrile; and

((3R,4S)-1-((5-chloropyridin-2-yl) sulfonyl)-4-(4-cyano-3-fluorophenoxy)-3-hydroxypyrrolidin-3-yl)methyl 2-aminoacetate;

or a pharmaceutically acceptable salt thereof.

6. The method of claim 1 wherein the compound is 4-(((3S,4S)-4-(aminomethyl)-1-((5-chloropyridin-2-yl) sulfonyl)-4-hydroxypyrrolidin-3-yl)oxy)-2-fluorobenzonitrile illustrated by a chemical structure of

or a pharmaceutically acceptable salt thereof.

7. The method of claim 1 wherein the compound or pharmaceutically acceptable salt thereof is administered orally.

8. The method of claim 1 wherein the compound or pharmaceutically acceptable salt thereof is administered intravenously.

9. The method of claim 1 wherein the compound or pharmaceutically acceptable salt thereof is administered by inhalation.

10. The method of claim 1 wherein the disease is ocular edema.

11. The method of claim 1 wherein the disease is glaucoma.

12. The method of claim 1 wherein the disease is retinopathy.

13. The method of claim 6 wherein the disease is ocular edema.

14. The method of claim 6 wherein the disease is glaucoma.

15. The method of claim 6 wherein the disease is retinopathy.

16. The method of claim 6 wherein the compound is

17. The method of claim 16 wherein the disease is ocular edema.

18. The method of claim 16 wherein the disease is glaucoma.

19. The method of claim 16 wherein the disease is retinopathy.

20. The method of claim 1 wherein the compound is 4-(((3S,4R)-4-(aminomethyl)-1-((5-chloropyridin-2-yl)sulfonyl)-4-hydroxypyrrolidin-3-yl)oxy)benzonitrile illustrated by a chemical structure of

or a pharmaceutically acceptable salt thereof.

21. The method of claim 20 wherein the compound is