IP Library Granted Patent US 11,793,472
Granted Patent B2
US 11,793,472 · App. 16/797,385 · Granted Oct 24, 2023

Systems and methods for the treatment of symptoms associated with migraines

Inventors: Marguerite Manteau-Rao (Boston, MA); Antoun Nabhan (Boston, MA)
Assignee: WELT Corp., Ltd
A61B5/7275G16H10/60G16H20/17G16H20/70A61B5/0004A61B5/02A61K38/225G16H20/13
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Quick Facts
Patent No.
US 11,793,472
App. No.
16/797,385
Granted
Oct 24, 2023
Kind
B2
Abstract

A method comprising executing a prescription digital therapeutic configured to treat symptoms associated with migraines experienced by a patient. Executing the prescription digital therapeutic comprises: (a) obtaining, by data processing hardware, a plurality of data from (i) first sensors associated with a patient electronic device, (ii) the patient via the patient electronic device, and (iii) a remote server; (b) weighting, by the data processing hardware, the plurality of data to provide a plurality of weighted data; (c) generating, by the data processing hardware, a migraine forecast prediction for the patient based on the plurality of weighted data; (d) determining, by the data processing hardware, a recommended dosage of a migraine-treating medication for the patient based on the migraine forecast prediction, the migraine-treating medication including one of a triptan or a calcitonin gene-related peptide (CGRP) inhibitor; and (e) instructing, by the data processing hardware, an administration unit to administer an administration dosage of the migraine-treating medication to the patient based on the recommended dosage.

Claims (36)

1. A system comprising:

a patient electronic device comprising:

data processing hardware; and

non-transitory memory hardware in communication with the data processing hardware, the memory hardware storing instructions that when executed on the data processing hardware cause the data processing hardware to perform operations comprising:

executing a prescription digital therapeutic by administering cognitive behavioral therapy through a series of graphical user interfaces of the prescription digital therapeutic which update in real-time to provide presentations via the patient electronic device as an interactive display on a display of the patient electronic device as a cognitive thinking game interface, the cognitive thinking game interface between the patient and the prescription digital therapeutic being configured to treat symptoms associated with migraines experienced by a patient through interaction with a game environment executed by a CBT module, wherein executing the prescription digital therapeutic comprises:

obtaining a plurality of data from (i) first sensors associated with the patient electronic device, (ii) the patient via the patient electronic device receiving one or more inputs from the patient through interaction with the game environment, and (iii) a remote server;

weighting the plurality of data to provide a plurality of weighted data;

generating a migraine forecast prediction for the patient based on the plurality of weighted data;

determining a recommended dosage of a migraine-treating medication for the patient based on the migraine forecast prediction, the migraine-treating medication including one of a triptan or a calcitonin gene-related peptide (CGRP) inhibitor; and

instructing an administration unit to administer an administration dosage of the migraine-treating medication to the patient based on the recommended dosage.

2. The system of claim 1 , further comprising the administration unit, wherein the administration unit is configured to administer the administration dosage of the migraine-treating medication to the patient based on the instructions.

3. The system of claim 2 , wherein the administration unit performs operations comprising:

administering the administration dosage of the migraine-treating medication to the patient.

4. The system of claim 1 , wherein executing the prescription digital therapeutic further comprises obtaining the plurality of data from second sensors associated with the patient, the second sensors comprising one or more of: (i) a heart rate monitor, (ii) a blood pressure monitor, (iii) a sleep monitor, (iv) an electrodermal activity monitor, (v) a skin temperature sensor, and (vi) a sweat monitor.

5. The system of claim 1 , wherein the first sensors associated with the patient electronic device comprise one or more of: (i) an accelerometer, (ii) a proximity sensor, (iii) an activity monitor, and (iv) a location system.

6. The system of claim 1 , wherein the plurality of data obtained from the patient via the input device comprise one or more of: (i) a migraine log, (ii) a migraine intensity indicator, (iii) a successful relief strategy, and (iv) a migraine-treating medication log.

7. The system of claim 1 , wherein the plurality of data obtained from the remote server comprise one or more of: (i) a temperature, (ii) a humidity, (iii) a cloud cover, and (iv) a barometric pressure.

8. The system of claim 1 , wherein weighting the plurality of data comprises assigning a first weight to a first data of the plurality of data and a second weight different than the first weight to a second data of the plurality of data.

9. The system of claim 1 , wherein the administration unit comprises one or more of: (i) a delivery pump, (ii) an injection unit, (iii) an implant, (iv) an oral absorption unit, (v) an inhaler, and (vi) a nasal injector.

10. A method comprising:

executing a prescription digital therapeutic by administering cognitive behavioral therapy through a series of graphical user interfaces of the prescription digital therapeutic which update in real-time to provide presentations via a patient electronic device as an interactive display on a display of the patient electronic device as a cognitive thinking game interface, the cognitive thinking game interface between the patient and the prescription digital therapeutic being configured to treat symptoms associated with migraines experienced by a patient through interaction with a game environment executed by the CBT module, wherein executing the prescription digital therapeutic comprises:

obtaining, by data processing hardware, a plurality of data from (i) first sensors associated with the patient electronic device, (ii) the patient via the patient electronic device receiving one or more inputs from the patient through interaction with the game environment, and (iii) a remote server;

weighting, by the data processing hardware, the plurality of data to provide a plurality of weighted data;

generating, by the data processing hardware, a migraine forecast prediction for the patient based on the plurality of weighted data;

determining, by the data processing hardware, a recommended dosage of a migraine-treating medication for the patient based on the migraine forecast prediction, the migraine-treating medication including one of a triptan or a calcitonin gene-related peptide (CGRP) inhibitor; and

instructing, by the data processing hardware, an administration unit to administer an administration dosage of the migraine-treating medication to the patient based on the recommended dosage.

11. The method of claim 10 , wherein the administration unit is configured to administer the administration dosage of the migraine-treating medication to the patient based on the instructions.

12. The method of claim 11 , wherein executing the prescription digital therapeutic further comprises administering, by the administration unit, the administration dosage of the migraine-treating medication to the patient.

13. The method of claim 10 , wherein executing the prescription digital therapeutic further comprises obtaining the plurality of data from second sensors associated with the patient, the second sensors comprising one or more of: (i) a heart rate monitor, (ii) a blood pressure monitor, (iii) a sleep monitor, (iv) an electrodermal activity monitor, (v) a skin temperature sensor, and (vi) a sweat monitor.

14. The method of claim 10 , wherein the first sensors associated with the patient electronic device comprise one or more of: (i) an accelerometer, (ii) a proximity sensor, (iii) an activity monitor, and (iv) a location system.

15. The method of claim 10 , wherein the plurality of data obtained from the patient via the input device comprise one or more of: (i) a migraine log, (ii) a migraine intensity indicator, (iii) a successful relief strategy, and (iv) a migraine-treating medication log.

16. The method of claim 10 , wherein the plurality of data obtained from the remote server comprise one or more of: (i) a temperature, (ii) a humidity, (iii) a cloud cover, and (iv) a barometric pressure.

17. The method of claim 10 , wherein weighting the plurality of data comprises assigning a first weight to a first data of the plurality of data and a second weight different than the first weight to a second data of the plurality of data.

18. The method of claim 10 , wherein the administration unit comprises one or more of: (i) a delivery pump, (ii) an injection unit, (iii) an implant, (iv) an oral absorption unit, (v) an inhaler, and (vi) a nasal injector.

19. The system of claim 1 , wherein the prescription digital therapeutic comprises a plurality of modules including at least one of: (i) an input module, (ii) a data weighting module, (iii) a prediction module, (iv) an education module, (v) a treatment and recommendation module, (vi) an administration module, (vii) or a cognitive behavioral therapy module.

20. The method of claim 10 , wherein the prescription digital therapeutic comprises a plurality of modules including at least one of: (i) an input module, (ii) a data weighting module, (iii) a prediction module, (iv) an education module, (v) a treatment and recommendation module, (vi) an administration module, (vii) or a cognitive behavioral therapy module.

Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 5, 2024
From: PEAR THERAPEUTICS (US), INC.
To: WELT CORP., LTD.
Reel/Frame 066345/0454 →
CHANGE OF NAME Recorded Apr 11, 2022
From: PEAR THERAPEUTICS, INC.
To: PEAR THERAPEUTICS (US), INC.
Reel/Frame 059561/0589 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 16, 2021
From: NABHAN, ANTOUN
To: PEAR THERAPEUTICS, INC.
Reel/Frame 056562/0501 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 15, 2021
From: MANTEAU-RAO, MARGUERITE
To: PEAR THERAPEUTICS, INC.
Reel/Frame 056552/0686 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 1, 2021
From: MANTEAU-RAO, MARGUERITE; NABHAN, ANTOUN
To: PEAR THERAPEUTICS, INC.
Reel/Frame 056402/0245 →
PATENT SECURITY AGREEMENT Recorded Jun 30, 2020
From: PEAR THERAPEUTICS, INC.
To: PERCEPTIVE CREDIT HOLDINGS III, LP
Reel/Frame 053095/0273 →
Continuity (2)
Provisional Application 62809251 · Feb 22, 2019
Related Publication 20200268324A1 · Aug 27, 2020