Filamentary devices for treatment of vascular defects
Methods and devices for treatment of a patient's cerebral aneurysm is described. The device includes a permeable shell having a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments that are woven together to form a mesh. The proximal ends of each of the plurality of filaments are gathered by a proximal hub and the distal ends of each of the plurality of filaments are gathered by a distal hub. The proximal portion of the permeable shell includes a swellable polymer. The method includes advancing the implant in a microcatheter to a region of interest in the cerebral vasculature, deploying the implant within the cerebral aneurysm, and withdrawing the microcatheter from the region of interest after deploying the implant.
1. A device for treatment of a patient's cerebral aneurysm, comprising a permeable shell including a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments that are woven together to form a mesh, the expanded state having a proximal portion and a distal portion, wherein each of the plurality of filaments has a proximal end and a distal end, and wherein the proximal ends of each of the plurality of filaments are gathered by a proximal hub and the distal ends of each of the plurality of filaments are gathered by a distal hub, wherein the proximal portion of the permeable shell comprises a swellable polymer.
2. The device of claim 1 , wherein the swellable polymer is disposed about a perimeter of the proximal portion of the permeable shell.
3. The device of claim 1 , wherein the permeable shell forms a shape in the expanded state selected from the group consisting of generally spherical, generally ovoid, and generally globular.
4. The device of claim 1 , wherein the permeable shell is adapted to reside within the aneurysm.
5. The device of claim 4 , wherein the device is adapted to span the neck of the aneurysm.
6. The device of claim 1 , wherein the plurality of filaments includes small filaments and large filaments.
7. The device of claim 6 , wherein the small filaments have a transverse diameter of about 0.015 mm to about 0.05 mm.
8. The device of claim 6 , wherein the large filaments have a transverse diameter of about 0.04 mm to about 0.1 mm.
9. The device of claim 1 , wherein the distal portion of the permeable shell in the expanded state has an everted configuration.
10. The device of claim 1 , wherein the proximal portion of the permeable shell in the expanded state has an everted configuration.
11. The device of claim 1 , wherein each elongate filament of the plurality of elongate filaments comprises a superelastic material.
12. The device of claim 11 , wherein the superelastic material is a shape memory metal.
13. The device of claim 12 , wherein the shape memory metal comprises a NiTi alloy.
14. The device of claim 1 , wherein a number of elongate filaments in the plurality of elongate filaments is greater than 125 filaments.
15. The device of claim 1 , wherein a number of elongate filaments in the plurality of elongate filaments is between about 80 and about 180 filaments.
16. The device of claim 1 , wherein a number of elongate filaments in the plurality of elongate filaments is between about 70 and about 300 filaments.
17. The device of claim 1 , wherein a number of elongate filaments in the plurality of elongate filaments is between about 100 and about 200 filaments.
18. The device of claim 1 , wherein the plurality of elongate filaments are braided.
19. The device of claim 1 , wherein the swellable polymer is disposed in a zone that extends from an apex of an outer proximal end radius for a distance to about 20% of a height of the expanded state of the permeable shell.
20. The device of claim 1 , wherein the swellable polymer is disposed on between about 5% and 30% of a surface area of the permeable shell.
21. The device of claim 1 , wherein the swellable polymer is incorporated in a proximal portion of the permeable shell.