Serdexmethylphenidate Conjugates, Compositions And Methods Of Use Thereof
The present technology is directed to one or more compositions comprising serdexmethylphenidate conjugates and unconjugated d-methylphenidate and/or a pharmaceutically acceptable salt thereof. The present technology also relates to one or more compositions and oral formulations comprising serdexmethylphenidate conjugates and unconjugated d-methylphenidate and/or a pharmaceutically acceptable salt thereof. The present technology also relates to one or more methods of using compositions comprising serdexmethylphenidate conjugates and unconjugated d-methylphenidate and/or a pharmaceutically acceptable salt thereof. The present technology additionally relates to one or more pharmaceutical kits containing a composition comprising serdexmethylphenidate conjugates and unconjugated d-methylphenidate and/or a pharmaceutically acceptable salt thereof.
1 . A method of treating a patient having Attention Deficit Hyperactivity Disorder (ADHD), comprising orally administering to the patient a pharmaceutically effective amount of a composition comprising serdexmethylphenidate and dexmethylphenidate in an amount of 26 mg serdexmethylphenidate and 5.2 mg dexmethylphenidate.
2 . The method of claim 1 , wherein the serdexmethylphenidate has the following struscture
3 . The method of claim 1 , wherein the serdexmethylphenidate is in the form of serdexmethylphenidate chloride, and wherein the 26 mg serdexmethylphenidate is equivalent to 28 mg serdexmethylphenidate chloride.
4 . The method of claim 3 , wherein the serdexmethylphenidate chloride has the following structure
5 . The method of claim 1 , wherein the dexmethylphenidate is in the form of dexmethylphenidate hydrochloride, and wherein the 5.2 mg dexmethylphenidate is equivalent to 6 mg dexmethylphenidate hydrochloride.
6 . The method of claim 1 , wherein the combined molar does of serdexmethylphenidate and dexmethylphenidate is equivalent to 20 mg of dexmethylphenidate hydrochloride.
7 . The method of claim 6 , wherein the 20 mg of dexmethylphenidate hydrochloride is equivalent to 17.3 mg dexmethylphenidate free base.
8 . The method of claim 1 , wherein the composition is in the form of a capsule or tablet.
9 . The method of claim 8 , wherein the capsule is an immediate release capsule.
10 . The method of claim 8 , wherein the capsule or tablet is contained in a blister pack.
11 . The method of claim 8 , wherein the capsule or tablet is administered as a dosage of 1 capsule or tablet every day.
12 . The method of claim 11 , wherein the dosage is of 1 capsule or tablet taken in the morning.
13 . The method of claim 8 , wherein the dosage is administered with or without food.
14 . The method of claim 13 , wherein the dosage is administered with food.
15 . The method of claim 8 , wherein the dosage is in the form of a capsule and the capsule is opened and the composition of the capsule is sprinkled onto a tablespoon of a semi-solid or a liquid.
16 . The method of claim 15 , wherein the semi-solid is applesauce.
17 . The method of claim 15 , wherein the liquid is water.
18 . A method of treating a patient having Attention Deficit Hyperactivity Disorder (ADHD), comprising orally administering to the patient a pharmaceutically effective amount of a composition comprising serdexmethylphenidate and dexmethylphenidate in an amount of 39 mg serdexmethylphenidate and 7.8 mg dexmethylphenidate.
19 . The method of claim 18 , wherein the serdexmethylphenidate has the following structure
20 . The method of claim 18 , wherein the serdexmethylphenidate is in the form of serdexmethylphenidate chloride, and wherein the 39 mg serdexmethylphenidate is equivalent to 42 mg serdexmethylphenidate chloride.
21 . The method of claim 20 , wherein the serdexmethylphenidate chloride has the following structure
22 . The method of claim 18 , wherein the dexmethylphenidate is in the form of dexmethylphenidate hydrochloride, and wherein the 7.8 mg dexmethylphenidate is equivalent to 9 mg dexmethylphenidate hydrochloride.
23 . The method of claim 18 , wherein the combined molar does of serdexmethylphenidate and dexmethylphenidate is equivalent to 30 mg of dexmethylphenidate hydrochloride.
24 . The method of claim 23 , wherein the 30 mg of dexmethylphenidate hydrochloride is equivalent to 25.9 mg dexmethylphenidate free base.
25 . The method of claim 18 , wherein the composition is in the form of a capsule or tablet.
26 . The method of claim 25 , wherein the capsule is an immediate release capsule.
27 . The method of claim 25 , wherein the capsule or tablet is contained in a blister pack.
28 . The method of claim 25 , wherein the capsule or tablet is administered as a dosage of 1 capsule or tablet every day.
29 . The method of claim 28 , wherein the dosage is of 1 capsule or tablet taken in the morning.
30 . The method of claim 25 , wherein the dosage is administered with or without food.
31 . The method of claim 30 , wherein the dosage is administered with food.
32 . The method of claim 25 , wherein the dosage is in the form of a capsule and the capsule is opened and the composition of the capsule is sprinkled onto a tablespoon of a semi-solid or a liquid.
33 . The method of claim 32 , wherein the semi-solid is applesauce.
34 . The method of claim 32 , wherein the liquid is water.
35 . A method of treating a patient having Attention Deficit Hyperactivity Disorder (ADHD), comprising orally administering to the patient a pharmaceutically effective amount of a composition comprising serdexmethylphenidate and dexmethylphenidate in an amount of 52 mg serdexmethylphenidate and 10.4 mg dexmethylphenidate.
36 . The method of claim 35 , wherein the serdexmethylphenidate has the following structure
37 . The method of claim 35 , wherein the serdexmethylphenidate is in the form of serdexmethylphenidate chloride, and wherein the 52 mg serdexmethylphenidate is equivalent to 56 mg serdexmethylphenidate chloride.
38 . The method of claim 37 , wherein the serdexmethylphenidate chloride has the following structure
39 . The method of claim 35 wherein the dexmethylphenidate is in the form of dexmethylphenidate hydrochloride, and wherein the 10.4 mg dexmethylphenidate is equivalent to 12 mg dexmethylphenidate hydrochloride.
40 . The method of claim 35 , wherein the combined molar does of serdexmethylphenidate and dexmethylphenidate is equivalent to 40 mg of dexmethylphenidate hydrochloride.
41 . The method of claim 40 , wherein the 40 mg of dexmethylphenidate hydrochloride is equivalent to 34.6 mg dexmethylphenidate free base.
42 . The method of claim 35 , wherein the composition is in the form of a capsule or tablet.
43 . The method of claim 42 , wherein the capsule is an immediate release capsule.
44 . The method of claim 42 , wherein the capsule or tablet is contained in a blister pack.
45 . The method of claim 42 , wherein the capsule or tablet is administered as a dosage of 1 capsule or tablet every day.
46 . The method of claim 45 , wherein the dosage is of 1 capsule or tablet taken in the morning.
47 . The method of claim 42 , wherein the dosage is administered with or without food.
48 . The method of claim 47 , wherein the dosage is administered with food.
49 . The method of claim 42 , wherein the dosage is in the form of a capsule and the capsule is opened and the composition of the capsule is sprinkled onto a tablespoon of a semi-solid or a liquid.
50 . The method of claim 49 , wherein the semi-solid is applesauce.
51 . The method of claim 49 , wherein the liquid is water.