Methods of reducing apolipoprotein c-III
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
1. A method of reducing an apolipoprotein C3 (APOC3) level of a subject on statin therapy and having baseline fasting triglycerides of about 200 mg/dl to about 499 mg/dl, the method comprising administering to the subject a pharmaceutical composition comprising ethyl eicosapentaenoate and docosapentaenoic acid daily for a period of 1 to about 12 weeks.
2. The method of claim 1 , wherein the APOC3 level is reduced by at least about 5%.
3. The method of claim 1 , wherein the APOC3 level is reduced by at least about 15%.
4. The method of claim 1 , wherein about 1 g to about 4 g of ethyl eicosapentaenoate is administered to the subject per day.
5. The method of claim 4 , wherein about 2 g per day of ethyl eicosapentaenoate is administered to the subject.
6. The method of claim 4 , wherein about 3.8 g to about 4 g per day of ethyl eicosapentaenoate is administered to the subject.
7. The method of claim 1 , wherein the reduction in APOC3 level is in comparison to control subjects having fasting triglycerides of about 200 mg/dl to about 499 mg/dl who have received the statin but not the pharmaceutical composition.
8. The method of claim 1 , wherein the pharmaceutical composition comprises at least about 95%, by weight of all fatty acids present, ethyl eicosapentaenoate.
9. The method of claim 1 , wherein the pharmaceutical composition comprises no more than about 10%, by weight of all fatty acids present, docosapentaenoic acid or a derivative thereof, if any.
10. The method of claim 1 , wherein the pharmaceutical composition comprises no more than about 10%, by weight of all fatty acids present, docosahexaenoic acid or a derivative thereof, if any.
11. A method of reducing an apolipoprotein C3 (APOC3) level of a subject having fasting baseline triglycerides of at least about 500 mg/dl, the method comprising administering to the subject a pharmaceutical composition comprising ethyl eicosapentaenoate and docosapentaenoic acid daily for a period of 1 to about 12 weeks.
12. The method of claim 11 , wherein the APOC3 level is reduced by at least about 5%.
13. The method of claim 11 , wherein the APOC3 level is reduced by at least about 25%.
14. The method of claim 11 , wherein about 1 g to about 4 g of ethyl eicosapentaenoate is administered to the subject per day.
15. The method of claim 14 , wherein about 2 g per day of ethyl eicosapentaenoate is administered to the subject.
16. The method of claim 14 , wherein about 3.8 g to about 4 g per day of ethyl eicosapentaenoate is administered to the subject.
17. The method of claim 11 , wherein the reduction in APOC3 level is in comparison to control subjects having fasting triglycerides of at least about 500 mg/dl who have not received the pharmaceutical composition.
18. The method of claim 11 , wherein the pharmaceutical composition comprises at least about 95%, by weight of all fatty acids present, ethyl eicosapentaenoate.
19. The method of claim 11 , wherein the pharmaceutical composition comprises no more than about 10%, by weight of all fatty acids present, docosapentaenoic acid or a derivative thereof, if any.
20. The method of claim 11 , wherein the pharmaceutical composition comprises no more than about 10%, by weight of all fatty acids present, docosahexaenoic acid or a derivative thereof, if any.