System and methods for preventative dental hard tissue treatment with a laser
This disclosure relates to various systems and methods related to preventative laser-based treatment of a dental tissue; for example, to prevent a patient from forming cavities. In some instances, a laser-based treatment system can generate a laser beam pulse with a fluence profile at a treatment site that results in either an increase in acid resistance of the tissue or removal of carbonate from the tissue, without melting or ablating the tissue. In some instances, the laser-based treatment system can direct the laser beam to various locations within a treatment site according to a temporal and/or spatial pattern, that results in either an increase in acid resistance of the tissue or removal of carbonate from the tissue, without melting or ablating the tissue. Many other systems and techniques for preventative and other laser-based treatment are also described.
1. A method of treating a dental hard tissue to resist acid dissolution by decreasing surface carbonate, the method comprising the steps of:
generating by using a CO 2 laser at least one pulse of a pulsed laser beam having a wavelength in a range from 8 to 12 microns and a pulse duration selected from a range of 0.1 to 100 microseconds;
defining a laser beam width of the pulsed laser beam and focusing the pulsed laser beam at or near a surface of the dental hard tissue using at least one optic;
controlling pulse energy of the pulsed laser beam based on the defined beam width, such that the at least one pulse of the pulsed laser beam has a fluence profile at a focus having:
a maximum local fluence less than an upper threshold fluence, the upper threshold fluence defined as a minimum fluence that causes a surface modification of the dental hard tissue, wherein the maximum local fluence is insufficient to cause surface modification comprising each of melting and ablation, and
at least one other local fluence greater than a lower threshold fluence, the lower threshold fluence defined as a fluence that causes a minimum decrease in an amount of surface carbonate of the dental hard tissue;
using a beam guidance system disposed down beam of the at least one optic to:
(i) direct a first laser pulse of the at least one pulse of the pulsed laser beam to an initial location within a treatment region at or near the surface of the dental hard tissue, such that a surface temperature of the initial location is raised from an initial surface temperature to a raised surface temperature during the first laser pulse, the raised temperature being below an upper temperature threshold defined as a minimum temperature that causes surface modification of the dental hard tissue;
(ii) thereafter, direct one or more intermediate laser pulses of the at least one pulse of the pulsed laser beam generated by the laser to one or more intermediate locations within the treatment region at or near the surface of the dental hard tissue; and
(iii) after (i) and (ii), direct another laser pulse of the at least one pulse of the pulsed laser beam to the initial location; and
thereafter, applying a post-treatment solution to the dental hard tissue.
2. The method of claim 1 , wherein the melting is determined by a visual inspection of a treated surface at least one of 200×, 500×, and 1000× magnification.
3. The method of claim 1 , wherein the ablation is determined by a visual inspection of a treated surface at least one of 200×, 500×, and 1000× magnification.
4. The method of claim 1 , wherein the acid dissolution resistance is determined by at least one of an acidic challenge and a pH cycling study.
5. The method of claim 4 , wherein the acidic challenge comprises using at least one of citric acid, acetic acid, and lactic acid.
6. The method of claim 1 , wherein the amount of surface carbonate is measured by at least one of reflectance FTIR, FTIR-ATR, Ramen Spectroscopy, and XRD.
7. The method of claim 1 , wherein the fluence profile further comprises at least one of a Gaussian profile, a near-Gaussian profile, and a top-hat profile.
8. The method of claim 1 , wherein controlling the pulse energy comprises controlling at least one of a pulse duration, average laser input power, and average laser output power.
9. The method of claim 1 , wherein the post-treatment solution comprises at least one of hydrogen peroxide, fluoride, chitosan, xylitol, calcium, and phosphate.
10. The method of claim 1 , wherein the laser pulse comprises a pulse energy in a range from 0.05 and 100 mJ.
11. The method of claim 1 , wherein the location comprises a width in a range from 0.1 to 10 millimeters.
12. The method of claim 1 , further comprising directing a fluid to flow at least one of onto and across the dental hard tissue.
13. The method of claim 12 , wherein the fluid comprises at least one of air, nitrogen, and water.
14. The method of claim 12 , wherein the fluid comprises a liquid.
15. The method of claim 12 , wherein the fluid comprises fluoride.
16. The method of claim 12 , wherein the fluid comprises a compressible fluid and the method further comprises expanding the fluid prior to directing the fluid upon the dental hard tissue.
17. The method of claim 12 , wherein the directing the fluid step is asynchronous with the generating the laser pulse step.
18. The method of claim 12 , wherein the directing the fluid step occurs during the generating the laser pulse step.
19. The method of claim 12 , further comprising adjusting a flow rate of the fluid sufficient to decrease the surface temperature of the location to a lowered temperature while no pulse burst is directed toward the location, wherein a sum of the lowered temperature and the temperature increase amount is at most equal to the raised temperature.
20. The method of claim 19 , wherein:
the fluid comprises compressed air; and
the flow rate is in a range from 1 SLPM to 100 SLPM.
21. The method of claim 12 , wherein the directing the fluid step comprises generating a negative pressure differential that causes the fluid to flow across the dental hard tissue.
22. The method of claim 12 , wherein the post-treatment solution comprises at least one of hydrogen peroxide, fluoride, chitosan, xylitol, calcium, and phosphate.
23. The method of claim 1 , wherein the post-treatment solution comprises fluoride.