Intravascular thromboembolectomy devices and methods
Devices and methods for increasing or restoring a flow in a body lumen. The devices and the methods may treat conditions like stroke by removing a clot from a blood vessel and/or reopen the vessel. The device may include a plurality of engaging elements, a central wire, and proximal control element. The device may include a linking structure between engaging elements. The linking structure may include segments configured to respond differently upon the application of longitudinal loads. The positions of the engaging elements and the distance therebetween can be adjusted simultaneously or sequentially to promote the engagement of the clot or occlusion. The device may include be configured to inhibit or prevent the proximal engaging element from being pulled back into a microcatheter when pulling the central wire to pull the distal engaging element proximally and/or during retraction of the device holding a clot.
1. A device for removing an obstruction from a body lumen, the device comprising:
a central wire comprising a proximal end and a distal end;
an engaging element at or near the distal end of the central wire; and
a microcatheter at least partially containing the engaging element during introduction into the body lumen,
wherein the engaging element is self-expandable upon unsheathing the microcatheter, and
wherein the engaging element, when expanded upon unsheathing from the microcatheter, is configured to inhibit re-sheathing of the engaging element in the microcatheter upon application of at least one of a proximal force to the engaging element or a distal force to the microcatheter.
2. The device according to claim 1 , wherein a proximal end of the engaging element comprises a stopper configured to expand radially upon unsheathing the engaging element from the microcatheter.
3. The device according to claim 2 , wherein the stopper comprises loops configured to bend radially outward upon unsheathing the engaging element from the microcatheter.
4. The device according to claim 2 , wherein the stopper comprises a spiral spring wire configured to expand radially outward upon unsheathing the engaging element from the microcatheter.
5. The device according to claim 1 , the engaging element comprises legs having a thickness configured to inhibit re-sheathing of the engaging element in the microcatheter when the legs are expanded.
6. The device according to claim 1 , wherein legs of the engaging element are at an angle of between 30° and 90° with respect to a longitudinal axis of the microcatheter when the legs are expanded.
7. The device according to claim 1 , wherein the engaging element comprises wires or struts.
8. The device according to claim 1 , wherein the engaging element is configured to inhibit re-sheathing of the microcatheter upon application of a proximal force of 50 grams to 450 grams.
9. The device according to claim 1 , further comprising a second engaging element located distal to the engaging element.
10. The device according to claim 9 , wherein the second engaging element is fixedly attached to the distal end of the central wire.
11. The device according to claim 10 , wherein the engaging element is slidable on the central wire.
12. The device according to claim 9 , comprising a linking connector coupled to the engaging element and the second engaging element, the linking connector spacing the engaging element and the second engaging element at a distance.
13. The device according to claim 12 , wherein the linking connector is a wire, a hypotube with slits, or a braid.
14. The device according to claim 9 , comprising a third engaging element located between the engaging element and the second engaging element.
15. The device according to claim 1 , wherein the engaging element is configured to inhibit re-sheathing at least while the device is withdrawn from the body lumen.
16. The device according to claim 1 , wherein the engaging element is configured to inhibit re-sheathing at least while a proximal end of the engaging element abuts a distal tip of the microcatheter.
17. A method of removing at least part of an occlusion from a body lumen, the method comprising:
introducing into the body lumen the device according to claim 1 , including the engaging element at least partially contained in the microcatheter, until the engaging element is proximate the occlusion;
deploying the engaging element from the microcatheter so that a distal tip of the microcatheter is proximal to the engaging element;
engaging at least part of the occlusion with the engaging element;
abutting the distal tip of the microcatheter with the proximal end of the engaging element; and
removing the engaged occlusion from the body lumen, wherein during the removing, the engaging element inhibits re-sheathing of the microcatheter over the engaging element.
18. The method according to claim 17 , wherein the proximal end of the engaging element comprises a stopper configured to expand radially upon unsheathing the microcatheter.
19. The method according to claim 17 , wherein legs of the engaging element have a thickness configured to inhibit re-sheathing of the microcatheter when the legs are expanded.
20. The method according to claim 17 , wherein legs of the engaging element are at an angle of between 30° and 90° with respect to a longitudinal axis of the microcatheter when the legs are expanded.
21. The method according to claim 17 , wherein abutting the distal tip of the microcatheter with the proximal end of the engaging element comprises proximally retracting the engaging element.
22. The method according to claim 17 , wherein removing the engaged occlusion is with the engaging element.
23. A device for removing an obstruction from a body lumen, the device comprising:
a central wire comprising a proximal end and a distal end;
an engaging element at or near the distal end of the central wire, wherein the engaging element comprises wires or struts; and
a microcatheter at least partially containing the engaging element during introduction into the body lumen,
wherein the engaging element, when expanded upon unsheathing from the microcatheter, is configured to inhibit re-sheathing of the engaging element in the microcatheter upon application of at least one of a proximal force to the engaging element or a distal force to the microcatheter.
24. A device for removing an obstruction from a body lumen, the device comprising:
a central wire comprising a proximal end and a distal end;
an engaging element at or near the distal end of the central wire; and
a microcatheter at least partially containing the engaging element during introduction into the body lumen,
wherein the engaging element, when expanded upon unsheathing from the microcatheter, is configured to inhibit re-sheathing of the engaging element in the microcatheter upon application of at least one of a proximal force to the engaging element or a distal force to the microcatheter at least while a proximal end of the engaging element abuts a distal tip of the microcatheter.