Treatment and diagnosis of inflammatory disorders and HIV
This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.
1. A method of treating autoimmune inflammatory ulcerative colitis consisting essentially of administering to a subject in need thereof an effective amount of a leukotoxin comprising SEQ ID NO: 1, wherein the ulcerative colitis is characterized by an influx of immune cells into the intestines and activation of leukocytes that express upregulated and activated leukocytes function antigen (LFA-1) on their surface to which the leukotoxin specifically binds.
2. The method of claim 1 , wherein the leukotoxin is prepared from Aggregatibacter actinomycetemcomitans.
3. The method of claim 1 , wherein the leukotoxin is purified.
4. The method of claim 1 , wherein the leukotoxin is administered with a pharmaceutically acceptable carrier.