Method of treating airway tissue to reduce mucus secretion
Systems and methods for treating a patient's mucus hypersecretion condition are disclosed herein. Certain implementations may involve a method for reducing mucus secretion in an upper airway of a patient to treat at least one of post nasal drip or chronic cough. The method may include advancing a treatment delivery portion of an energy-based treatment device into a nostril of the patient. The treatment delivery portion may contact mucosal tissue of the upper airway without piercing the mucosal tissue. The treatment delivery portion may deliver treatment to at least one tissue selected from the group of the mucosal tissue and another tissue underlying the mucosal tissue to modify a property of the at least one tissue and thus treat at least one of post nasal drip or chronic cough in the patient.
1. A method for treating mucus producing cells in an airway of a patient to reduce mucus secretion, the method comprising:
advancing a treatment delivery portion of an energy-based treatment device into a nostril and thus into the airway of the patient;
contacting mucosal tissue of the airway with the treatment delivery portion, without piercing the mucosal tissue; and
delivering energy from the treatment delivery portion to a selected tissue depth to modify at least one property of the mucus producing cells and thus reduce mucus secretion in the airway.
2. The method of claim 1 , wherein delivering the energy comprises delivering a form of energy selected from the group consisting of heat, radiofrequency, laser, light, ultrasound, microwave, electromechanical, mechanical, cooling, alternating current, direct current, chemical, electrochemical, and cryogenic energy.
3. The method of claim 1 , wherein the mucus producing cells are selected from the group consisting of cilia, goblet cells, and submucosal cells.
4. The method of claim 1 , wherein delivering the energy comprises delivering radiofrequency energy from a first row of bipolar electrodes to a second row of bipolar electrodes on the treatment delivery portion, wherein each electrode of the first row of electrodes is paired with a corresponding electrode of the second row of electrodes, so that the two rows of bipolar radiofrequency electrodes form multiple electrode pairs, and wherein delivering the radiofrequency energy comprises delivering radiofrequency energy between the multiple electrode pairs.
5. The method of claim 4 , wherein at least part of a treatment surface of the treatment delivery portion is convex, and wherein delivering the radiofrequency energy comprises delivering the radiofrequency energy in a convex shape from the first row to the second row of bipolar electrodes.
6. The method of claim 5 , wherein the electrodes of the two rows of bipolar electrodes comprise non-piercing bumps on the treatment surface, and wherein contacting the mucosal tissue comprises contacting the non-piercing bumps with the mucosal tissue.
7. The method of claim 1 , further comprising:
measuring a temperature of the mucosal tissue using a thermocouple located on the treatment delivery portion; and
adjusting an amount of energy delivered by the treatment delivery portion, based on the measured temperature, by adjusting a setting of the treatment device.
8. The method of claim 1 , further comprising applying force against the mucosal tissue with the treatment delivery portion to mechanically alter a shape of the airway while delivering the energy.
9. The method of claim 8 , wherein a treatment surface of the treatment delivery portion is convex.
10. The method of claim 1 , wherein delivering the energy modifies the at least one property by changing the mucus producing cells to a different type of cells.
11. The method of claim 1 , further comprising adjusting a shaft of the treatment device to change an angle of the treatment delivery portion relative to the shaft.
12. The method of claim 1 , wherein the at least one property modified by delivering the energy comprises the ability of the mucus producing cells to engage in a vesicle-membrane fusion process.