IP Library Granted Patent US 11,504,719
Granted Patent B2
US 11,504,719 · App. 16/816,817 · Granted Nov 22, 2022

System and method for receiving and delivering a fluid for sample processing

Inventors: Kalyan Handique (Ann Arbor, MI); Austin Payne (Ann Arbor, MI)
Assignee: Bio-Rad Laboratories, Inc.
B01L3/563B01L2200/0684B01L2300/165G01N2001/002
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Quick Facts
Patent No.
US 11,504,719
App. No.
16/816,817
Granted
Nov 22, 2022
Kind
B2
Abstract

A system and method for receiving and delivering a fluid, the system comprising: a body configured to interface with an opening of a reservoir and defining: a protrusion defining a set position of the body relative to the reservoir; a wall extending from the protrusion; a receiving surface coupled to the wall and sloping from an apex to a nadir along a first direction, the receiving surface comprising a vent; and an outlet positioned closer to the nadir than the apex of the receiving surface and displaced from the vent, the outlet comprising an extension from the body, the extension configured to contact an interior wall of the reservoir, wherein the body comprises: a bubble-mitigating operation mode in which the receiving surface receives and transmits the fluid along the receiving surface, and a fluid-transmitting operation mode in which the body directs the fluid along the interior wall of the reservoir.

Claims (19)

1. A system for receiving and delivering a fluid, the system comprising:

a body configured to interface with an opening of a reservoir and defining:

a protrusion defining a set position of the body relative to the opening of the reservoir;

a wall extending from the protrusion;

a receiving surface coupled to the wall and sloping from an apex to a nadir along a first direction, the receiving surface comprising a vent; and

an outlet positioned closer to the nadir than the apex of the receiving surface and displaced from the vent, the outlet comprising an extension from the body, the extension configured to contact an interior wall of the reservoir,

wherein the body is thermally coupled to a heating or cooling element, which comprises a thermal control operation mode in which the heating or cooling element controls a temperature of the fluid contacting the body, and wherein the body comprises:

a bubble-mitigating operation mode in which the receiving surface receives the fluid from a container elevated above the body and transmits the fluid along the receiving surface toward the nadir, thereby transitioning the sample processing fluid from a bubble-rich state to a reduced-bubble state, and

a fluid-transmitting operation mode in which the body directs the fluid, in the reduced-bubble state, through the outlet, along the extension, and along the interior wall of the reservoir toward a base of the reservoir in a bubble-free state.

2. The system of claim 1 , wherein the receiving surface is concave in a cross section taken across a plane normal to the first direction.

3. The system of claim 1 , wherein the receiving surface comprises a textured region comprising at least one of: a set of recesses and a set of protrusions configured to disrupt bubbles from the fluid.

4. The system of claim 1 , wherein the protrusion positions the receiving surface within the reservoir, with the extension of the outlet directing a stream of the fluid to the interior wall of the reservoir during operation.

5. The system of claim 1 , wherein the receiving surface slopes from a horizonal plane at an angle from 10-50 degrees from the apex to the nadir.

6. The system of claim 1 , wherein the body comprises a set of surfaces comprising the receiving surface, each of the set of surfaces comprising a respective outlet and configured such that an upstream outlet transmits the fluid toward a downstream surface of the set of surfaces.

7. The system of claim 1 , wherein the vent comprises a boundary at least partially formed by the wall of the body.

8. The system of claim 1 , wherein the extension extends from a side of the body opposing the receiving surface and toward the interior wall of the reservoir.

9. The system of claim 1 , wherein the body comprises a set of extensions coupled to one or more outlets comprising the outlet, and wherein the set of extensions extend from the one or more outlets toward a set of contact positions of the interior wall of the reservoir.

10. The system of claim 1 , wherein the vent is positioned at the apex of the receiving surface and wherein the outlet is positioned at the nadir of the receiving surface.

11. The system of claim 1 , further comprising a force-transmitting element coupled to the body and configured to transmit force to the fluid for actively disrupting bubbles of the fluid.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 5, 2020
From: CELSEE, INC.
To: BIO-RAD LABORATORIES, INC.
Reel/Frame 054269/0742 →
CHANGE OF NAME Recorded Sep 24, 2020
From: CELSEE DIAGNOSTICS, INC.
To: CELSEE, INC.
Reel/Frame 053881/0555 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 20, 2020
From: HANDIQUE, KALYAN; PAYNE, AUSTIN
To: CELSEE DIAGNOSTICS, INC.
Reel/Frame 052181/0799 →
Continuity (1)
Related Publication 20210283613A1 · Sep 16, 2021
Cited By (1)
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