Aromatic-cationic peptides and uses of same
The disclosure provides compositions and methods relating to aromatic-cationic peptides. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof. For example, the peptides may be administered to subjects in need of a mitochondrial-targeted antioxidant.
1. An aromatic-cationic peptide consisting of the amino acid sequence D-Arg-4-methoxy-2,6-dimethyltyrosine-Lys-Phe-NH 2 , or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising the aromatic-cationic peptide or pharmaceutically acceptable salt thereof of claim 1 .
3. The pharmaceutical composition of claim 2 further comprising a pharmaceutically acceptable carrier.
4. A method of reducing the number of mitochondria undergoing mitochondrial permeability transition (MPT), or preventing mitochondrial permeability transitioning in a mammal in need thereof, the method comprising administering to the mammal an effective amount of the aromatic-cationic peptide or pharmaceutically acceptable salt thereof of claim 1 .
5. A method for reducing oxidative damage in a mammal in need thereof, the method comprising administering to the mammal an effective amount of the aromatic-cationic peptide or pharmaceutically acceptable salt thereof of claim 1 .
6. A method for increasing the ATP synthesis rate in a mammal in need thereof, the method comprising administering to the mammal an effective amount of the aromatic-cationic peptide or pharmaceutically acceptable salt thereof of claim 1 .