TOPICAL COMPOSITIONS AND METHODS FOR TREATING ACNE VULGARIS
Topical pharmaceutical compositions comprise a combination of retinoid and an antibacterial agent. In particular, a topical composition comprises tretinoin and benzoyl peroxide. Such compositions are used for treating acne vulgaris.
1 . A method of treating acne vulgaris, comprising: administering topically a therapeutically effective amount of a composition comprising tretinoin at a concentration of about 0.01-0.1 weight percent and benzoyl peroxide at a concentration of about 1-5 weight percent, to an affected area, at a frequency and for a period of time sufficient to treat said acne vulgaris; wherein said concentrations are based on weight percent of the composition, and said tretinoin and benzoyl peroxide are present together in the composition.
2 . The method of claim 1 ; wherein the tretinoin concentration is about 0.04-0.06 weight percent, and the benzoyl peroxide concentration is about 2-3 weight percent.
3 . The method of claim 1 ; wherein the tretinoin concentration is about 0.05 weight percent, and the benzoyl peroxide concentration is about 2.5 weight percent.
4 . The method of claim 1 ; wherein said administering is carried out 1 or 2 times daily for 1-24 weeks.
5 . The method of claim 3 ; wherein said administering is carried out once daily for 12 weeks.
6 . The method of claim 3 ; wherein said administering is carried out once daily for 24 weeks.
7 . The method of claim 3 ; wherein said composition is an admixture of a first composition comprising tretinoin and a second composition comprising benzoyl peroxide.
8 . The method of claim 7 ; wherein said first composition and said second composition are admixed substantially immediately prior to said administering.
9 . A topical pharmaceutical composition for treating acne vulgaris, comprising: tretinoin at a concentration of about 0.01-0.1 weight percent of the composition and benzoyl peroxide at a concentration of about 1-5 weight percent of the composition.
10 . The composition of claim 9 ; wherein the tretinoin concentration is about 0.04-0.06 weight percent of the composition, and the benzoyl peroxide concentration is about 2-3 weight percent of the composition.
11 . The composition of claim 9 ; wherein the tretinoin concentration is about 0.05 weight percent of the composition, and the benzoyl peroxide concentration is about 2.5 weight percent of the composition
12 . The composition of claim 9 ; wherein the composition is a gel.
13 . The composition of claim 12 ; wherein said gel is an aqueous gel.
14 . The composition of claim 9 ; wherein said composition comprises an admixture of a first amount of a first composition comprising tretinoin and a second mount of a second composition comprising benzoyl peroxide; wherein a tretinoin concentration of said first composition and a benzoyl peroxide concentration of said second composition are sufficient to provide tretinoin at about 0.05 weight percent and benzoyl peroxide at about 2.5 weight percent of said admixture.
15 . The composition of claim 14 ; wherein weights of said first amount and said second amount are approximately equal.
16 . The composition of claim 9 ; wherein said composition comprises an admixture of a first composition comprising tretinoin at a concentration of about 0.1 weight percent, and a second composition comprising benzoyl peroxide at a concentration of about 5 weight percent.
17 . The composition of claim 16 ; wherein the tretinoin of the composition is stable at 32 degrees C., for about 24 hours.
18 . The composition of claim 16 ; wherein the tretinoin of the composition is stable at 32 degrees C., for about 24 hours under room light condition.
19 . The composition of claim 16 ; wherein the tretinoin of the composition is stable at room condition for about 24 hours.
20 . The composition of claim 16 ; wherein more than 95 percent of the tretinoin of the composition remains after 24 hours at 32 degrees C. under room light.