Coal-based graphene biosensors
View Patent ↗An example method includes providing coal and extracting the graphene from the coal. The graphene may be extracted using any suitable technique, such as the Hummers method, a modified Hummers method, or exfoliation of graphite. The graphene may include impurities or other electrical properties that depend at least partially on the composition of the coal. The method may further include forming a life science device from the graphene. The life science device may include, for example, a biosensor or a drug delivery system.
1. A method to form a life science device, the method comprising:
extracting an amount of graphene from coal, the graphene having at least one property at least partially dependent on a composition of the coal; and
forming a life science device from the amount of graphene by disposing at least one graphene layer on a substrate to form a biosensor, the at least one graphene layer comprising one or more binding sites configured to bind or otherwise react with one or more targets;
functionalizing at least some of the at least one graphene layer to form the one or more binding sites, wherein functionalizing at least some of the at least one graphene layer comprises functionalizing impurities naturally present in the graphene layer, wherein the impurities naturally present in the graphene layer comprise hexavalent metals.
2. The method of claim 1 , wherein disposing the at least one graphene layer on the substrate comprises:
disposing a first graphene layer on the substrate to form a first subsensor; and
disposing a second graphene layer on the substrate to form a second subsensor that is spaced apart from the first subsensor;
wherein the first graphene layer comprises a first binding site and the second graphene layer comprises a second binding site that is different from the first binding site.
3. The method of claim 1 , further comprising forming one or more electrical contacts on the at least one graphene layer or the substrate.
4. The method of claim 1 , further comprising attaching one or more sensitive biological elements to the at least one graphene layer.
5. The method of claim 1 , wherein forming the life science device from the amount of graphene comprises rolling at least some of the amount of graphene into a carbon nanotube to form a drug delivery system.
6. A method of forming graphene for use in a life science device from coal, the method comprising:
analyzing a characteristic of an amount of coal; and
extracting an amount of graphene from the amount of coal, the graphene having at least one property at least partially dependent on the characteristic of the coal, wherein the characteristic of the coal comprises hexavalent metals present in the coal.
7. The method of claim 6 , wherein extracting the amount of graphene from the amount of coal comprises extracting the graphene from the coal using the Hummers method or a modified Hummers method.
8. The method of claim 6 , wherein extracting the amount of graphene from the amount of coal comprises exfoliating graphite that is present in the coal.
9. The method of claim 6 , wherein the characteristic further comprises at least one of a carbon, aromaticity, heavy metal, or ash content of the amount of coal.
10. The method of claim 6 , further comprising selecting one or more parameters of an extraction technique that is used to extract the amount of graphene from the amount of coal based at least partially on the characteristic.
11. The method of claim 6 , further comprising evaluating the amount of graphene to determine a property of the graphene.
12. The method of claim 11 , wherein the property comprises at least one of an average flake size, a graphene purity, an average number of carbon layers, a presence of impurities, a composition of the impurities, electrical properties, or thermal properties.
13. The method of claim 12 , further comprising selecting at least some graphene exhibiting the property from the amount of graphene for use in the life science device.
14. The method of claim 6 , further comprising functionalizing at least some of the amount of graphene.
15. The method of claim 6 , further comprising forming at least some of the amount of graphene into the life science device.
16. A biosensor comprising:
a substrate;
a graphene layer disposed on the substrate, the graphene layer comprising graphene formed from coal and having a property at least partially dependent on a characteristic of the coal, wherein the graphene layer comprises a functionalization group including impurities naturally present in the graphene layer, wherein the impurities naturally present in the graphene layer comprise hexavalent metals; and
a binding site bonded to the graphene, the binding site configured to bind or otherwise react with one or more targets.
17. The biosensor of claim 16 , further comprising a first subsensor and a second subsensor spaced apart from the first subsensor;
the first subsensor comprising a first binding site and the second subsensor comprising a second binding site that is different from the first binding site.
18. The biosensor of claim 16 , wherein the biosensor comprises at least one of an amperometric biosensor, a conductometric biosensor, a potentiometric biosensor, impedimetric biosensor or a field-effect transistor biosensor.
19. The biosensor of claim 16 , wherein the biosensor comprises at least one of a rapid diagnostic biosensor, a sequencing biosensor, a cancer detection biosensor, or a biosensor for personalized medicine.
20. The biosensor of claim 16 , wherein the biosensor comprises an enzyme-linked immunosorbent assay.