Succinylcholine prefilled syringe, compositions and methods
View Patent ↗Pre-filled syringes, pharmaceutical compositions, and kits and methods relating to same allow for emergency administration of one or more drugs from prefilled glass syringes to a patient via a needleless connector. In preferred embodiments, the prefilled glass syringe has a drug volume of at least 5 mL, has a Luer-lock, and has a syringe tip with an internal channel that has a diameter of about 1.7 mm. Such syringes advantageously allow storage of emergency drugs without leaching of plastic materials and degradation, and substantially improve the safety profile where the syringe is attached to an IV line via a needleless connector.
1. A kit comprising:
a prefilled glass syringe containing a succinylcholine composition;
wherein the succinylcholine composition has a pH of about 3.0 to about 4.5;
wherein the succinylcholine composition disposed in the glass syringe contains not more than about 6% total impurities after storage at 2-8° C. for 15 months, followed by storage at about 25° C. for 14 days as determined by HPLC; and
wherein the syringe has a Luer-lock and a syringe tip with an internal channel that has a diameter of about 1.7 mm.
2. The kit of claim 1 , wherein the glass syringe has a volume of at least 5 mL.
3. The kit of claim 1 , wherein the succinylcholine composition has an osmolality of about 260 to about 340 mOsm/kg.
4. The kit of claim 1 , wherein the succinylcholine chloride is present in the succinylcholine composition in an amount of about 20 mg/mL and sodium chloride is present in the succinylcholine composition in an amount of about 6 mg/mL.
5. The kit of claim 1 , wherein the succinylcholine composition further comprises a pH adjusting agent.
6. The kit of claim 5 , wherein the pH adjusting agent is hydrochloric acid and/or sodium hydroxide.
7. The kit of claim 1 , wherein the pH of the succinylcholine composition is about 3.6.
8. The kit of claim 1 , wherein the syringe has a glide force of about 1 to about 20 N.
9. The kit of claim 1 , wherein the syringe has a break loose force of about 10 to about 30 N.
10. The kit of claim 1 , wherein the syringe contains about 5 mL of the succinylcholine composition, or wherein the syringe contains about 10 mL of the succinylcholine composition.
11. The kit of claim 1 , wherein the succinylcholine composition comprises succinylcholine chloride, sodium chloride, and water, wherein the succinylcholine composition is substantially free of preservatives.
12. The kit of claim 1 , wherein the succinylcholine composition disposed in the glass syringe contains not more than about 6% total impurities and no more than 4% succinylmonocholine chloride after storage at 2-8° C. for 15 months, followed by storage at about 25° C. for 14 days, as determined by HPLC.
13. The kit of claim 1 , wherein the succinylcholine composition disposed in the glass syringe contains not more than about 4% succinylmonocholine chloride after storage at 2-8° C. for 15 months, followed by storage at about 25° C. for 14 days, as determined by HPLC.
14. The kit of claim 1 , wherein the succinylcholine composition disposed in the glass syringe contains not more than about 1% succinic acid after storage at 2-8° C. for 15 months, followed by storage at about 25° C. for 14 days, as determined by HPLC.